Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator
Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator
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DOI：
10.1073/pnas.0703451104
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发表时间：
2007-07-24
影响因子：
11.1
通讯作者：
Ziotnik, Albert
中科院分区：
文献类型：
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作者：
Hever, Aniko;Roth, Richard B.;Ziotnik, Albert
子宫内膜异位症影响10-20%的育龄妇女，并与盆腔疼痛和不孕症有关，其发病机制尚不清楚。我们使用全基因组转录谱来表征子宫内膜异位症，发现它表现出与潜在的自身免疫机制一致的基因表达特征。子宫内膜异位症病变的特征在于存在大量的浆细胞，其中许多产生IgM，以及产生BLyS/BAFF/TNFSF 13 B的巨噬细胞，所述BLyS/BAFF/TNFSF 13 B是与其他自身免疫性疾病有关的TNF超家族的成员。子宫内膜异位症患者血清中B淋巴细胞刺激因子（BLyS）蛋白水平升高。这些观察结果提示了一种子宫内膜异位症的病理模型，其中BLyS反应性浆细胞与逆行月经组织相互作用，引起子宫内膜异位症病变。
Endometriosis affects 10-20% of women of reproductive age and is associated with pelvic pain and infertility, and its pathogenesis is not well understood. We used genomewide transcriptional profiling to characterize endometriosis and found that it exhibits a gene expression signature consistent with an underlying autoimmune mechanism. Endometriosis lesions are characterized by the presence of abundant plasma cells, many of which produce IgM, and macrophages that produce BLyS/BAFF/TNFSF13B, a member of the TNF superfamily implicated in other autoimmune diseases. B lymphocyte stimulator (BLyS) protein was found elevated in the serum of endometriosis patients. These observations suggest a model for the pathology of endometriosis where BLyS-responsive plasma cells interact with retrograde menstrual tissues to give rise to endometriosis lesions.