Metabolic changes in human brain evolution.
Metabolic changes in human brain evolution.
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DOI：
10.1002/evan.21831
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发表时间：
2020-04
影响因子：
3.7
通讯作者：
A. Bauernfeind;C. Babbitt
中科院分区：
文献类型：
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作者：
A. Bauernfeind;C. Babbitt
由于人类的大脑比其他灵长类动物的大脑大得多，因此其能量需求远远超过该目中任何物种也就不足为奇了。最近，干细胞技术和单细胞转录组学的发展为解决人类大脑独特表型背后的特定基因组变化这一问题提供了新的方法。在这篇综述中，我们使用从脑成像、体视学到转录组学等多种方法来考虑目前对人类大脑代谢的了解。接下来，我们研究干细胞技术和单细胞转录组学为进一步了解人类大脑能量学提供的新机会。这些新的实验方法提供了阐明基因序列和表达水平变化的功能影响的能力，这些变化可能对人类大脑的进化产生深远的影响。
Because the human brain is considerably larger than those of other primates, it is not surprising that its energy requirements would far exceed that of any of the species within the order. Recently, the development of stem cell technologies and single-cell transcriptomics provides novel ways to address the question of what specific genomic changes underlie the human brain's unique phenotype. In this review, we consider what is currently known about human brain metabolism using a variety of methods from brain imaging and stereology to transcriptomics. Next, we examine novel opportunities that stem cell technologies and single-cell transcriptomics provide to further our knowledge of human brain energetics. These new experimental approaches provide the ability to elucidate the functional effects of changes in genetic sequence and expression levels that potentially had a profound impact on the evolution of the human brain.