Inter‐hemispheric desynchronization of the human MT+ during visually induced motion sickness
Inter‐hemispheric desynchronization of the human MT+ during visually induced motion sickness
复制标题
视觉引起的晕动病期间人类 MT+ 的半球间去同步化
DOI：
10.1007/s00221-015-4312-y
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Higuchi T.
中科院分区：
文献类型：
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作者：
Miyazaki J;Yamamoto H;Ichimura Y;Yamashiro H;Murase T;Yamamoto T;Umeda M;Higuchi T.
视觉诱发运动病（VIMS）是由敏感个体静止观看移动的视觉场景而引发的。VIMS通常在自我运动错觉（vection）和/或与人类运动敏感中颞区（MT+）活动增加相关的不适当视动性眼震（OKN）反应之前发生。神经影像学研究报告称，在vection和OKN期间，MT+的右半球激活占主导地位，这表明VIMS可能是由左右MT+皮质之间的活动失同步引起的。然而，这种可能性尚未得到直接测试。为此，我们提出了VIMS的自由和VIMS诱导的电影，同时测量相应的左，右视觉皮层（包括MT+）之间的时间相关性，使用功能性磁共振成像。在报告VIMS的MT+受试者中，与对照无VIMS电影相比，在观看VIMS诱导电影期间，半球间相关性显著降低，但在不敏感受试者中则不然。相比之下，在V1、V2、V3、V3 A或V7视觉区，无VIMS或VIMS诱导的电影暴露内没有显著的半球间差异。我们的研究结果提供了第一个证据异步双边MT+激活和VIMS之间的关联。左右MT+区域的去极化可能反映了参与眼动控制、向量感知和/或姿势控制的功能网络活动的半球不对称性。
Visually induced motion sickness (VIMS) is triggered in susceptible individuals by stationary viewing of moving visual scenes. VIMS is often preceded by an illusion of self-motion (vection) and/or by inappropriate optokinetic nystagmus (OKN) responses associated with increased activity in the human motion-sensitive middle temporal area (MT+). Neuroimaging studies have reported predominant right hemispheric activation in MT+ during both vection and OKN, suggesting that VIMS may result from desynchronization of activity between left and right MT+ cortices. However, this possibility has not been directly tested. To this end, we presented VIMS-free and VIMS-inducing movies in that order while measuring the temporal correlations between corresponding left and right visual cortices (including MT+) using functional magnetic resonance imaging. The inter-hemispheric correlation was reduced significantly during the viewing of the VIMS-inducing movie compared to the control VIMS-free movie in the MT+ of subjects reporting VIMS, but not in insusceptible subjects. In contrast, there were no significant inter-hemispheric differences within VIMS-free or VIMS-inducing movie exposure for visual area V1, V2, V3, V3A or V7. Our findings provide the first evidence for an association between asynchronous bilateral MT+ activation and VIMS. Desynchronization of left and right MT+ regions may reflect hemispheric asymmetry in the activities of functional networks involved in eye movement control, vection perception and/or postural control.