Weight loss and lipid changes with low-energy diets: Comparator study of milk-based versus soy-based liquid meal replacement interventions
Weight loss and lipid changes with low-energy diets: Comparator study of milk-based versus soy-based liquid meal replacement interventions
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DOI：
10.1080/07315724.2005.10719467
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发表时间：
2005-06-01
影响因子：
3.5
通讯作者：
Hoie, LH
中科院分区：
文献类型：
--
作者：
Anderson, JW;Hoie, LH
目的：大豆蛋白摄入对实验动物的体重和脂肪分布有有利的影响，但这些影响尚未在人类身上得到证实。为了比较大豆代餐 (MR) 与牛奶代餐 (MR) 的效果，我们评估了食用低能量饮食 (LED)（包括牛奶或大豆 MR）的肥胖受试者的体重减轻和血清脂蛋白变化。方法：超重或肥胖女性和男性（体重指数 27-40 kg/m(2)）被随机分配到提供 1200 kcal/天的 LED，摄入 5 种或 2 种大豆代餐。 牛奶液体 MR 进行为期 12 周的减肥试验。在基线、第 6 周和第 12 周获得血清脂蛋白测量结果。结果：对于大豆和牛奶 MR 组，受试者数量分别为 51 名和 39 名随机受试者以及 30 名和 22 名完成者。 MR 平均使用量：大豆，3.7 次/天；和牛奶，1.9/天。 12 周时完成者的体重减轻为： 大豆 MR，初始体重的 9.0%（95% 置信区间，7.3-10.6%）；和牛奶 MR 分别为 7.9% (5.8-8.8%)，无显着差异。六周时，大豆 MR（15.2% 和 17.4%）的血清胆固醇和 LDL-胆固醇值相对于基线的降低分别显着高于（P < 0.015）牛奶 MR（7.9% 和 7.7%）。使用大豆 MR 与第 6 周和 12 周时血清甘油三酯的显着降低相关，而使用牛奶 MR 则不然。结论：作为低能量饮食的一部分，使用大豆 MR 在 12 周内与使用牛奶 MR 相比，体重减轻略有但不显着。这些观察结果证实了之前的研究记录了 MR 用于减肥的有效性。
Objectives: Soy protein intake has favorable effects on body weight and fat distribution in experimental animals but these effects have not been demonstrated in humans. To compare effects of soy- vs. milk-based meal replacements (MR) we assessed weight loss and serum lipoproteins changes for obese subjects who consumed low-energy diets (LED) including either milk-based or soy-based MR.Methods: Overweight or obese women and men (body mass indices 27-40 kg/m(2)) were randomly assigned to LED providing 1200 kcal/day, with consumption of five soy-based or two milk-based liquid MR for a 12-week weight loss trial. Serum lipoprotein measurements were obtained at baseline, 6 and 12 weeks.Results: For soy and milk MR groups, subject numbers were, respectively, 51 and 39 randomized and 30 and 22 completers. MR use averaged: soy, 3.7/day; and milk, 1.9/day. Weight losses for completers at 12 weeks were: soy MR, 9.0% of initial body weight (95% confidence intervals, 7.3-10.6%); and milk MR, 7.9% (5.8-8.8%) with no significant differences. Reductions from baseline in serum cholesterol and LDL-cholesterol values, respectively, at six weeks were significantly greater (P < 0.015) with soy MR (15.2% and 17.4%) than with milk MR (7.9% and 7.7%). Soy MR use was associated with significant reductions in serum triglycerides at 6 and 12 weeks while milk MR use was not.Conclusions: Soy MR use, as part of a low-energy diet, was associated with slightly but not significantly greater weight loss over a 12-week period than milk MR use. These observations confirm previous studies documenting the effectiveness of MR use for weight loss.