Cellular functions of the ADF/cofilin family at a glance
Cellular functions of the ADF/cofilin family at a glance
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DOI：
10.1242/jcs.187849
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发表时间：
2016-09-01
影响因子：
4
通讯作者：
Frame, Margaret C.
中科院分区：
文献类型：
--
作者：
Kanellos, Georgios;Frame, Margaret C.
肌动蛋白解聚因子（ADF）/cofilin家族包括在发育、组织稳态和疾病中具有关键作用的小肌动蛋白结合蛋白。它们最为人所知的作用是通过促进肌动蛋白微铣削来调节肌动蛋白动力学，从而驱动膜突起和细胞运动。然而，最近的发现增加了我们对这些蛋白质的功能的理解，超越了它们的明确特征。这篇Cell Science at a Glance文章和随附的海报介绍了ADF/cofilin家族在细胞中的不同作用。文章的第一部分总结了他们的行动在肌动蛋白酶的铣削和细胞内调节的主要机制;第二部分的目的是提供一个轮廓的新兴细胞的角色归因于ADF/cofilin家族，除了他们的行动在肌动蛋白营业额。后一部分讨论了一系列不同的过程，其中包括细胞内收缩力的调节，核完整性的维持，转录调控，核肌动蛋白单体转移，细胞凋亡和脂质代谢。当然，其中一些可能是肌动蛋白蛋白研磨功能的间接结果，并对此进行了讨论。
The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins with crucial roles in development, tissue homeostasis and disease. They are best known for their roles in regulating actin dynamics by promoting actin treadmilling and thereby driving membrane protrusion and cell motility. However, recent discoveries have increased our understanding of the functions of these proteins beyond their well-characterized roles. This Cell Science at a Glance article and the accompanying poster serve as an introduction to the diverse roles of the ADF/cofilin family in cells. The first part of the article summarizes their actions in actin treadmilling and the main mechanisms for their intracellular regulation; the second part aims to provide an outline of the emerging cellular roles attributed to the ADF/cofilin family, besides their actions in actin turnover. The latter part discusses an array of diverse processes, which include regulation of intracellular contractility, maintenance of nuclear integrity, transcriptional regulation, nuclear actin monomer transfer, apoptosis and lipid metabolism. Some of these could, of course, be indirect consequences of actin treadmilling functions, and this is discussed.