The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
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DOI：
10.1111/jnc.15271
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发表时间：
2021-05
影响因子：
4.7
通讯作者：
Geller HM
中科院分区：
文献类型：
--
作者：
Agbaegbu Iweka C;Hussein RK;Yu P;Katagiri Y;Geller HM
磷脂磷酸酶相关蛋白1（PLPPR 1）是脂质磷酸酶相关蛋白家族的成员，其特征在于六个跨膜结构域的整合膜蛋白。这个蛋白质家族在大脑中富集，最近的数据表明在几种不同的情况下具有潜在的多效性功能。这个家族的蛋白质的一个固有的能力是诱导形态学的变化，我们以前曾报道，这个家庭的成员相互作用，并可能合作。然而，PLPPR 1的功能尚未被理解。在这里，我们表明，PLPPR 1的表达减少硫酸软骨素蛋白多糖和神经元2a细胞的神经突起的回缩的神经突起生长的抑制培养的小鼠海马神经元由溶血磷脂酸（LPA）。此外，我们表明，PLPPR1减少激活Ras同源家族成员A（RhoA）的LPA在神经2a细胞，这是由于PLPPR1与Rho特异性鸟嘌呤核苷酸解离抑制剂（RhoGDI1）的协会。这些结果为PLPPR 1蛋白建立了一种新的信号通路。
Phospholipid Phosphatase-Related Protein Type 1 (PLPPR1) is a member of a family of lipid phosphatase related proteins, integral membrane proteins characterized by six transmembrane domains. This family of proteins is enriched in the brain and recent data indicate potential pleiotropic functions in several different contexts. An inherent ability of this family of proteins is to induce morphological changes, and we have previously reported that members of this family interact with each other and may function co-operatively. However, the function of PLPPR1 is not yet understood. Here we show that expression of PLPPR1 reduces the inhibition of neurite outgrowth of cultured mouse hippocampal neurons by chondroitin sulfate proteoglycans and the retraction of neurites of Neuro-2a cells by lysophosphatidic acid (LPA). Further, we show that PLPPR1 reduces the activation of Ras homolog family member A (RhoA) by LPA in Neuro-2a cells, and that this due to an association of PLPPR1with the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI1). These results establish a novel signaling pathway for the PLPPR1 protein.
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