Detection of non-linearity in schizophrenic patients using magnetoencephalography
Detection of non-linearity in schizophrenic patients using magnetoencephalography
复制标题
DOI：
10.1023/a:1021420507901
复制
发表时间：
2002-12-01
期刊：
影响因子：
2.7
通讯作者：
Anninos, P
中科院分区：
文献类型：
--
作者：
Kotini, A;Anninos, P
目的：本研究旨在探讨精神分裂症患者与对照组颞叶脑磁图（MEG）记录中是否存在非线性，以发现潜在的脑电波差异。我们计算了关联维数，这是衡量动态系统的复杂性，以及第一个李雅普诺夫指数，表明系统的不可预测性。研究方法：精神分裂症组包括3名男性和7名女性，年龄23-32岁（平均27.2，SD=3.5），对照组包括3名男性和6名女性，年龄26-35岁（平均31.6+/- 4.1）。就年龄和性别而言，两组之间没有显著差异。他们都没有接受任何药物治疗。结果如下：精神分裂症患者脑磁图的分析显示，与对照组相比，精神分裂症患者脑磁图的维数复杂度较低，第一李雅普诺夫指数也较低，说明精神分裂症患者脑磁图的信息加工能力较低。结论：脑磁图和非线性分析所确定的脑电图结果可能提供重要的观点，以更好地了解精神分裂症的脑功能。
Objective: The aim of this study is to investigate the presence of any non-linearity in the magnetoencephalographic recordings (MEG) from the temporal lobe of schizophrenic patients in comparison with controls, in order to find the differences underlying the brain waves. We calculated the correlation dimension, which is a measure of the complexity of the dynamic system, as well as the first Lyapunov exponent that indicates the system's unpredictability. Methods: The schizophrenic group consisted of 3 men and 7 women aged 23-32 years (mean 27.2, SD=3.5) and the control group of 3 men and 6 women aged 26-35 years (mean 31.6+/- 4.1). There were no significant differences between the two groups as far as age and sex were concerned. None of them received any medication. Results: The analysis of the MEG in the schizophrenic group showed lower dimension complexity and moreover the first Lyapunov exponent presented lower values compared with the corresponding ones in the control group, which means lower information processing. Conclusion: EEG findings as determined by MEG and non-linear analysis may offer important perspectives to better understand brain function in schizophrenia.