Paternal Environmental Toxicant Exposure and Risk of Adverse Pregnancy Outcomes.
Paternal Environmental Toxicant Exposure and Risk of Adverse Pregnancy Outcomes.
复制标题
父亲环境有毒物质的暴露和不良怀孕结果的风险。
DOI：
10.1007/s13669-019-00265-w
复制
发表时间：
2019
影响因子：
0.5
通讯作者：
Osteen KG
中科院分区：
文献类型：
--
作者：
Bruner-Tran KL;Mokshagundam S;Barlow A;Ding T;Osteen KG
目前预测和预防早产的临床努力主要集中在母亲身上，在改善结局方面进展甚微。然而，最近的数据表明，父亲的因素也会影响出生的时间。在这里，我们将回顾最近的人类和小鼠数据，检查父亲对怀孕结果的贡献，重点放在可能对生育和出生时间产生负面影响的环境暴露。人类流行病学研究现在清楚地表明，各种父亲因素(年龄、种族、体重、吸烟状况)可以影响精子质量、出生时间，在一些研究中，还会影响后代的健康。利用小鼠模型，我们的数据已经证明，发育过程中暴露于环境毒物TCDD(2，3，7，8-四氯二苯并-对二恶英)与精子数量和质量的跨代减少以及未暴露的伴侣早产风险的增加有关。毒物接触史会明显影响人和小鼠的精子质量。老鼠的数据进一步表明，对精子质量产生负面影响的暴露也会损害胎盘功能，可能会导致早产和其他不良后果。尤其令人担忧的是，这些变化与男性生殖细胞内的表观遗传变化有关，然后这些变化可能会在多代之间传播。由于在人类人群中不可能预防祖先毒物的暴露，因此应该探索在未孕期可以实施的生活方式改变以提高精子质量的治疗潜力，以减少肺结核及其后遗症的发生率。
Current clinical efforts to predict and prevent preterm birth are primarily focused on the mother and have made minimal progress in improving outcomes. However, recent data indicate that paternal factors can also influence timing of birth. Herein, we will review recent human and murine data examining the contribution of the father to pregnancy outcomes with an emphasis on environmental exposures that can negatively impact fertility and the timing of birth. Human epidemiology studies now clearly indicate that a variety of paternal factors (age, race, weight, smoking status) can influence sperm quality, birth timing and, in some studies, offspring health. Utilizing a mouse model, our data have 57demonstrated that developmental exposure to the environmental toxicant TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is associated with a transgenerational reduction in sperm number and quality and an increased risk of preterm birth in an unexposed partner. Toxicant exposure history can clearly influence sperm quality in men and mice. Murine data further indicate that exposures which negatively affect sperm quality also impair placental function, potentially leading to preterm birth and other adverse outcomes. Of particular concern, these changes have been linked to epigenetic alterations within the male germ cell which can then be transmitted across multiple generations. Since it is not possible to prevent an ancestral toxicant exposure in a human population, identifying lifestyle modifications that can be implemented during the preconception period to improve sperm quality should be explored for the therapeutic potential to reduce the incidence of PTB and its sequelae.
登录
查看更多内容
影响因子：
0.5
作者：
Bruner-Tran, Kaylon L;Resuehr, David;Ding, Tianbing;Lucas, John A;Osteen, Kevin G
通讯作者：
Osteen, Kevin G
影响因子：
7.4
作者：
Banderali G;Martelli A;Landi M;Moretti F;Betti F;Radaelli G;Lassandro C;Verduci E
通讯作者：
Verduci E
影响因子：
3.7
作者：
Bruner-Tran, Kaylon L.;Ding, Tianbing;Osteen, Kevin G.
通讯作者：
Osteen, Kevin G.
DOI：
10.1080/07488009408409164
发表时间：
1994-07-01
期刊：
Medicine and war
影响因子：
--
作者：
Doucet, I
通讯作者：
Doucet, I
DOI：
10.1080/1362369042000248811
发表时间：
2004-07-01
期刊：
Medicine, conflict, and survival
影响因子：
--
作者：
Emmerova, Milada;Jirava, Frantisek
通讯作者：
Jirava, Frantisek