Comparison of red and green light for treating non-muscle invasive bladder cancer in rats using singlet oxygen-cleavable prodrugs with PPIX-PDT.
Comparison of red and green light for treating non-muscle invasive bladder cancer in rats using singlet oxygen-cleavable prodrugs with PPIX-PDT.
复制标题
使用单线态氧可裂解前药与 PPIX-PDT 治疗大鼠非肌肉浸润性膀胱癌的红光和绿光比较。
DOI：
10.1111/php.13933
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发表时间：
2024
影响因子：
3.3
通讯作者：
You,Youngjae
中科院分区：
文献类型：
--
作者：
Rahman,KaziMdMahabubur;Kumbham,Soniya;Bist,Ganesh;Woo,Sukyung;Foster,BarbaraA;You,Youngjae
Photofrin-PDT 在加拿大被批准用于治疗膀胱癌已有 30 年了。然而，由于膀胱并发症，Photofrin-PDT 未能普及。红光 PDT 和静脉注射 Photofrin 可能会永久性损伤膀胱肌肉。我们一直在开发一种新的 PpIX-PDT 与单线态氧可裂解前药的组合策略，用于 NMIBC，副作用最小，避免膀胱肌肉层损伤。 PpIX 可以被绿光 (532 nm) 或红光 (635 nm) 激发。红光在体内可能更有效，因为它比绿光具有更深的组织穿透力。由于 HAL 优先在肿瘤中产生 PpIX，我们假设用红光照射 PpIX 可能不会伤害肌肉层。 PpIX-PDT 用于比较绿色和红色激光的体外和体内功效。体外 PpIX-PDT 的 IC50 值（红色激光）为 18 mW/cm2，绿色激光为 22 mW/cm2。总剂量为 50、75 和 100 mW 的红色激光在缩小肿瘤体积方面的体内功效与相同剂量的绿色激光相似。将 PpIX-PDT 与前药甲基连接的丝裂霉素 C (Mt-L-MMC) 和罗丹明连接的 SN-38 (Rh-L-SN-38) 组合可显着提高疗效（肿瘤体积比较）。在组织学分析中，PpIX-PDT 或 PpIX-PDT + 前药组合不会引起肌肉损伤。总体而言，PpIX-PDT 和前药与 635 nm 激光的组合有望用于非肌层浸润性膀胱癌的治疗。
It has been 30 years since Photofrin‐PDT was approved for the treatment of bladder cancer in Canada. However, Photofrin‐PDT failed to gain popularity due to bladder complications. The PDT with red light and IV‐administered Photofrin could permanently damage the bladder muscle. We have been developing a new combination strategy of PpIX‐PDT with singlet oxygen‐cleavable prodrugs for NMIBC with minimal side effects, avoiding damage to the bladder muscle layer. PpIX can be excited by either green (532 nm) or red (635 nm) light. Red light could be more efficacious in vivo due to its deeper tissue penetration than green light. Since HAL preferentially produces PpIX in tumors, we hypothesized that illuminating PpIX with red light might spare the muscle layer. PpIX‐PDT was used to compare green and red laser efficacy in vitro and in vivo. The IC50of in vitro PpIX‐PDT was 18 mW/cm2with the red laser and 22 mW/cm2with the green laser. The in vivo efficacy of the red laser with 50, 75, and 100 mW total dose was similar to the same dose of green laser in reducing tumor volume. Combining PpIX‐PDT with prodrugs methyl‐linked mitomycin C (Mt‐L‐MMC) and rhodamine‐linked SN‐38 (Rh‐L‐SN‐38) significantly improved efficacy (tumor volume comparison). PpIX‐PDT or PpIX‐PDT + prodrug combination did not cause muscle damage in histological analysis. Overall, a combination of PpIX‐PDT and prodrug with 635 nm laser is promising for non‐muscle invasive bladder cancer treatment.
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一项1B阶段的术中光动力疗法的临床研究对患有Calmette-guérin-无抑制性非肌肉侵入性膀胱癌的患者的临床研究。
影响因子：
2.5
作者：
Kulkarni, Girish S.;Lilge, Lothar;Nesbitt, Michael;Dumoulin-White, Roger J.;Mandel, Arkady;Jewett, Michael A. S.
通讯作者：
Jewett, Michael A. S.
影响因子：
4.6
作者：
Taroni P;Paganoni AM;Ieva F;Pifferi A;Quarto G;Abbate F;Cassano E;Cubeddu R
通讯作者：
Cubeddu R
影响因子：
254.7
作者：
Siegel, Rebecca L.;Miller, Kimberly D.;Jemal, Ahmedin
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Jemal, Ahmedin
蓝光膀胱镜检查用于检测和治疗非肌层浸润性膀胱癌。
DOI：
--
发表时间：
2012
期刊：
The Canadian journal of urology
影响因子：
--
作者：
J. Mark;F. Gelpi‐Hammerschmidt;E. Trabulsi;L. Gomella
通讯作者：
L. Gomella
使用卟啉钠的光动力疗法作为难治性膀胱原位移行细胞癌患者膀胱切除术的替代疗法。
影响因子：
6.6
作者：
U. Nseyo;B. Shumaker;E. Klein;K. Sutherland
通讯作者：
K. Sutherland