Functional neuroimaging evidence for hyperarousal in insomnia
Functional neuroimaging evidence for hyperarousal in insomnia
复制标题
DOI：
10.1176/appi.ajp.161.11.2126
复制
发表时间：
2004-11-01
影响因子：
17.7
通讯作者：
Kupfer, DJ
中科院分区：
文献类型：
--
作者：
Nofzinger, EA;Buysse, DJ;Kupfer, DJ
目的：方法：采用[F-18]氟脱氧葡萄糖正电子发射断层扫描（FDG）技术，对7例失眠症患者和20例正常对照者的脑局部葡萄糖代谢进行检测。与健康受试者相比，失眠患者在睡眠和清醒时表现出更高的整体大脑葡萄糖代谢，从清醒到睡眠状态的唤醒促进区域的相对代谢下降较小，而清醒时前额皮质的相对代谢减少。结论：失眠患者主观睡眠障碍与大脑代谢增加有关。无法入睡可能与唤醒机制失败有关，无法从清醒状态下降到睡眠状态。此外，日间疲劳可能反映了由于睡眠不足导致的前额叶皮层活动减少。
Objective: The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia.Method: [F-18]Fluorodeoxyglucose positron emission tomography was used to assess regional cerebral glucose metabolism of seven patients with insomnia and 20 healthy subjects.Results: Compared with healthy subjects, patients with insomnia showed greater global cerebral glucose metabolism during sleep and while awake, a smaller decline in relative metabolism from waking to sleep states in wake-promoting regions, and reduced relative metabolism in the prefrontal cortex while awake.Conclusions: Subjectively disturbed sleep in patients with insomnia is associated with greater brain metabolism. The inability to fall asleep may be related to a failure of arousal mechanisms to decline in activity from waking to sleep states. Further, daytime fatigue may reflect decreased activity in the prefrontal cortex resulting from inefficient sleep.