Impaired Mitochondrial Transcription Factor A Expression Promotes Mitochondrial Damage to Drive Fibroblast Activation and Fibrosis in Systemic Sclerosis
Impaired Mitochondrial Transcription Factor A Expression Promotes Mitochondrial Damage to Drive Fibroblast Activation and Fibrosis in Systemic Sclerosis
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DOI：
10.1002/art.42033
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发表时间：
2021-11
影响因子：
13.3
通讯作者：
Xiang Zhou;T. Trinh-Minh;C. Tran-Manh;A. Giessl;C. Bergmann;A. Györfi;G. Schett;J. Distler
中科院分区：
文献类型：
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作者：
Xiang Zhou;T. Trinh-Minh;C. Tran-Manh;A. Giessl;C. Bergmann;A. Györfi;G. Schett;J. Distler
线粒体转录因子A（TFAM）控制线粒体稳态所需的核心蛋白的转录。本研究旨在研究系统性硬化症（SSc）中TFAM表达的变化，分析线粒体功能，并评估成纤维细胞活化的后果。
Mitochondrial transcription factor A (TFAM) controls the transcription of core proteins required for mitochondrial homeostasis. This study was undertaken to investigate changes in TFAM expression in systemic sclerosis (SSc), to analyze mitochondrial function, and to evaluate the consequences for fibroblast activation.