Efficient Receptive Field Tiling in Primate V1.
Efficient Receptive Field Tiling in Primate V1.
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DOI：
10.1016/j.neuron.2016.07.015
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发表时间：
2016-08-17
期刊：
影响因子：
16.2
通讯作者：
Callaway EM
中科院分区：
文献类型：
--
作者：
Nauhaus I;Nielsen KJ;Callaway EM
初级视觉皮层(V1)编码了一组不同的视觉特征，包括方位、眼优势(OD)和空间频率(SF)，其联合组织必须被精确地构造以优化视网膜地图的覆盖。以往的实验只确定了基于正交图的有效覆盖。在这里，我们使用双光子钙成像揭示了猕猴V1的OD和SF图的另一种排列；它们的梯度平行但具有独特的空间周期，因此低SF区域与单目区域重合。接下来，我们映射了感受野，发现了令人惊讶的精确的显微视网膜复制，它产生了更小的点图像，需要更有效的映射间几何图形，从而强调了映射关系的重要性。虽然顺畅的视网膜复制受到限制，但研究表明，它既改善了布线经济性，也改善了下游的V1群体代码读取。总而言之，这些数据表明，在单个神经元的水平上，V1内的连接是微调和精确的。
The primary visual cortex (V1) encodes a diverse set of visual features, including orientation, ocular dominance (OD) and spatial frequency (SF), whose joint organization must be precisely structured to optimize coverage within the retinotopic map. Prior experiments have only identified efficient coverage based on orthogonal maps. Here, we used two-photon calcium imaging to reveal an alternative arrangement for OD and SF maps in macaque V1; their gradients run parallel but with unique spatial periods, whereby low SF regions coincide with monocular regions. Next, we mapped receptive fields and find surprisingly precise micro-retinotopy that yields a smaller point-image and requires more efficient inter-map geometry, thus underscoring the significance of map relationships. While smooth retinotopy is constraining, studies suggest that it improves both wiring economy and the V1 population code read downstream. Altogether, these data indicate that connectivity within V1 is finely tuned and precise at the level of individual neurons.