Pulsatile local delivery of thrombolytic and antithrombotic agents using poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels
Pulsatile local delivery of thrombolytic and antithrombotic agents using poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels
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DOI：
10.1016/0168-3659(95)00134-4
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发表时间：
1996-03-01
影响因子：
10.8
通讯作者：
Peppas, NA
中科院分区：
文献类型：
--
作者：
Brazel, CS;Peppas, NA
合成了聚（N-异丙基丙烯酰胺-co-甲基丙烯酸）水凝胶，并研究了其作为抗血栓药物的pH和温度触发递送装置。对于含有大于75摩尔% NIPAAm的水凝胶，pH和温度敏感性都影响网络的整体溶胀行为。将链激酶和肝素装载到这些水凝胶中，并在脉动条件下测定其释放特性。在这项研究中合成的水凝胶能够脉冲链激酶释放，与溶胀和塌陷的水凝胶状态之间的释放速率至少一个数量级的差异。然而，小得多的肝素分子在塌陷和溶胀的聚合物状态下同样迅速地扩散。
Hydrogels of poly(N-isopropylacrylamide-co-methacrylic acid) were synthesized and investigated as pH- and temperature-triggered delivery devices for antithrombotic agents. For hydrogels containing greater than 75 mol% NIPAAm, the pH and temperature sensitivity both influenced the overall swelling behavior of the networks. Streptokinase and heparin were loaded into these hydrogels and their release characteristics were determined under pulsatile conditions. The hydrogels synthesized in this study were capable of pulsatile streptokinase release, with at least one order of magnitude difference in release rates between the swollen and collapsed hydrogel states. However, the much smaller heparin molecule diffused equally rapidly in the collapsed and swollen polymer states.