Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis
Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis
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DOI：
10.1097/00006676-199808000-00010
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发表时间：
1998-08-01
期刊：
影响因子：
2.9
通讯作者：
Korc, M
中科院分区：
文献类型：
--
作者：
Kornmann, M;Beger, HG;Korc, M
成纤维细胞生长因子（FGF）家族是一组同源肝素结合多肽，其与多种人类肿瘤有关，目前包括14个成员。FGF信号传导由双受体系统介导，由四种高亲和力酪氨酸激酶受体（称为成纤维细胞生长因子受体（FGFR））和增强配体呈递至FGFR的低亲和力硫酸乙酰肝素蛋白聚糖受体组成。几种FGF，包括FGF-1、FGF-2、FGF-3、FGF-4、FGF-5、FGF-6和FGF-7，以及几种FGFR变体，其中包括FGFR-1的2免疫球蛋白样形式和IIIc剪接变体，以及角质形成细胞生长因子受体，FGFR-2的剪接变体，在人胰腺癌细胞系中表达并且在人胰腺癌或慢性胰腺炎的胰腺中过表达，因此，可能在这些胰腺疾病的病理生物学中发挥重要作用。本文就FGF家族及其受体与胰腺癌和慢性胰腺炎的关系作一综述。
The fibroblast growth factor (FGF) family is a group of homologous heparin-binding polypeptides that has been implicated in a variety of human neoplasms and presently includes 14 members. FGF signaling is mediated by a dual-receptor system, consisting of four high-affinity tyrosine kinase receptors, termed fibroblast growth factor receptors (FGFRs), and of low-affinity heparan sulfate proteoglycan receptors that enhance ligand presentation to the FGFRs. Several FGFs, including FGF-1, -2, -3, -4, -5, -6, and -7, and several FGFR variants, among them the 2 immunoglobulin-like form and the IIIc splice variant of FGFR-1 and the keratinocyte growth factor receptor, a splice variant of FGFR-2, are expressed in human pancreatic cancer cell lines and are overexpressed in human pancreatic cancers or in the pancreas of chronic pancreatitis and, therefore, may play important roles in the pathobiology of these pancreatic diseases. This review summarizes the current information on the involvement of the FGF family and their receptors in human pancreatic cancer and chronic pancreatitis.