G Protein-Coupled Receptor Kinases: Crucial Regulators of Blood Pressure.
G Protein-Coupled Receptor Kinases: Crucial Regulators of Blood Pressure.
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DOI：
10.1161/jaha.116.003519
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发表时间：
2016-07-07
影响因子：
5.4
通讯作者：
Zeng C
中科院分区：
文献类型：
--
作者：
Yang J;Villar VA;Armando I;Jose PA;Zeng C
Hypertension, a complex trait determined by genetic, epigenetic, and environmental factors and their intricate interaction, is an important public health challenge worldwide because of its high prevalence and concomitant increase in the risk for cardiovascular disease. Unfortunately, the prevalence of hypertension is increasing in both developed and developing countries. 1 As a consequence of the increase in global prevalence, the total number of adults with hypertension is predicted to increase to 1.56 billion in 2025. 2 This prospect is daunting, given that, in 2010, high blood pressure was already the biggest single contributor to global mortality and disease burden.The pathogenesis of essential hypertension is complex. Many organs and systems including kidneys, arteries, microcirculation, heart, immune system, nervous system, and endocrine factors are involved in the pathophysiology of hypertension. Among them, kidneys and arteries are major contributors to the development of hypertension. 3, 4 Various agonists binding to plasma membrane receptors regulate renal sodium transport and fluid balance and maintain the equilibrium between vasoconstriction and vasodilation. Many of these agonists transmit their “information” via G protein–coupled receptors (GPCRs). GPCRs mediate cellular responses to diverse extracellular stimuli and play a vital role in the control of physiology and behavior. 5 GPCR kinases (GRKs) interact with the agonist-activated GPCRs to promote receptor
