Apoptotic cells, including macrophages, are prominent in Theiler's virus-induced inflammatory, demyelinating lesions
Apoptotic cells, including macrophages, are prominent in Theiler's virus-induced inflammatory, demyelinating lesions
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DOI：
10.1128/jvi.77.7.4383-4388.2003
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发表时间：
2003-04-01
影响因子：
5.4
通讯作者：
Lipton, HL
中科院分区：
文献类型：
--
作者：
Schlitt, BP;Felrice, M;Lipton, HL
Theiler小鼠脑脊髓炎病毒（TMEV）主要存在于小鼠中枢神经系统的巨噬细胞中，培养的受感染巨噬细胞发生凋亡。我们已经检测到大量的凋亡细胞在血管周围袖口和炎症，脱髓鞘病变的SJL小鼠慢性感染TMEV。凋亡细胞中T细胞占74%，巨噬细胞占8%，星形胶质细胞占0.6%，还有17%未被识别。原位杂交显示病毒RNA在凋亡细胞中的比例接近1%。
Theiler's murine encephalomyelitis virus (TMEV) persists in the mouse central nervous system principally in macrophages, and infected macrophages in culture undergo apoptosis. We have detected abundant apoptotic cells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected with TMEV. T cells comprised 74% of apoptotic cells, while 8% were macrophages, 0.6% were astrocytes, and similar to17% remained unidentified. In situ hybridization revealed viral RNA in similar to1% of apoptotic cells.