Pre-clinical research in small animals using radiotherapy technology - a bidirectional translational approach
Pre-clinical research in small animals using radiotherapy technology - a bidirectional translational approach
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DOI：
10.1016/j.zemedi.2014.07.004
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发表时间：
2014-01-01
影响因子：
2
通讯作者：
Enghardt, Wolfgang
中科院分区：
文献类型：
--
作者：
Tillner, Falk;Thute, Prasad;Enghardt, Wolfgang
对于转化性癌症研究，使用小动物的临床前体内研究在弥合体外细胞实验和临床实施之间的差距方面已成为不可或缺的。在建立这种小动物实验时，必须考虑各种生物学、技术和方法方面的问题。在这项工作中，我们提出了一个全面的专题审查的基础上，用于临床前癌症研究的小鼠和大鼠的辐射技术的相关出版物。根据动物模型和实验目标，适用于体外放射治疗和近距离放射治疗的临床放射治疗设备以及专用研究照射设备适用于小动物照射。在这项工作中，适当的解决方案，人类放射肿瘤学的技术转移到小动物放射研究进行了总结。此外，还提供了有关实验设计的重要信息，以便获得可靠和临床相关的结果。
For translational cancer research, pre-clinical in-vivo studies using small animals have become indispensable in bridging the gap between in-vitro cell experiments and clinical implementation. When setting up such small animal experiments, various biological, technical and methodical aspects have to be considered. In this work we present a comprehensive topical review based on relevant publications on irradiation techniques used for pre-clinical cancer research in mice and rats. Clinical radiotherapy treatment devices for the application of external beam radiotherapy and brachytherapy as well as dedicated research irradiation devices are feasible for small animal irradiation depending on the animal model and the experimental goals. In this work, appropriate solutions for the technological transfer of human radiation oncology to small animal radiation research are summarised. Additionally, important information concerning the experimental design is provided such that reliable and clinically relevant results can be attained.