VAGAL TONE DECREASES FOLLOWING INTRAVENOUS DIAZEPAM
VAGAL TONE DECREASES FOLLOWING INTRAVENOUS DIAZEPAM
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DOI：
10.1016/0165-1781(92)90101-8
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发表时间：
1992-02-01
影响因子：
11.3
通讯作者：
LINNOILA, M
中科院分区：
文献类型：
--
作者：
ADINOFF, B;MEFFORD, I;LINNOILA, M
为了研究焦虑和副交感神经系统活动之间的关系，在6名健康志愿者静脉注射抗焦虑药地西泮后评估了心脏迷走神经张力。迷走神经张力通过量化呼吸性窦性心律失常的幅度来确定。我们观察到迷走神经张力的显著剂量依赖性衰减，伴有心率增加。在较高剂量的地西泮下，血浆去甲肾上腺素浓度和主观焦虑评分无统计学显著性降低。我们讨论了副交感神经系统在苯二氮卓类药物的抗焦虑作用中的可能作用。
To investigate the relationship between anxiety and parasympathetic nervous system activity, cardiac vagal tone was assessed in six healthy volunteers after the intravenous administration of the anxiolytic diazepam. Vagal tone was determined by quantifying the amplitude of respiratory sinus arrhythmia. We observed a significant dose-dependent attenuation in vagal tone, accompanied by an increase in heart rate. There was a nonstatistically significant decrease in plasma norepinephrine concentrations and subjective anxiety ratings at higher doses of diazepam. We discuss a possible role of the parasympathetic nervous system in the anxiolytic effects of the benzodiazepines.