Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging
Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging
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DOI：
10.3945/ajcn.2008.26987
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发表时间：
2009-07-01
影响因子：
7.1
通讯作者：
Laurin, Danielle
中科院分区：
文献类型：
--
作者：
Kroeger, Edeltraut;Verreault, Rene;Laurin, Danielle
背景资料：Omega-3多不饱和脂肪酸（n-3 PUFA）可以预防痴呆，尽管流行病学研究得出了不确定的结果。鱼类是n-3多不饱和脂肪酸的主要膳食来源，有时会受到汞污染。目的：我们评估了加拿大健康与老龄化研究（CSHA）中红细胞膜总n-3 PUFAs、二十二碳六烯酸（DHA）、二十碳五烯酸（EPA）和血汞与痴呆和阿尔茨海默病（AD）发病率的关系，并调整了混杂因素，包括载脂蛋白E β 4设计：CSHA是1991年至2002年进行的年龄≥ 65岁的代表性样本的队列研究。663例非痴呆CSHA受试者的子样本有完整的临床检查、血液样本和随访信息，有资格进行实验室测量的前瞻性分析。其中，149例痴呆症的事件，包括105 AD。结果：在调整后的考克斯回归模型与年龄的时间尺度，有没有总n-3 PUFAs，DHA，EPA和痴呆症或AD之间的关联。相反，汞浓度在最高四分位数与痴呆风险降低相关（风险比：0.53; 95% CI：0.33，0.88）。然而，显著的风险降低仅限于n-3 PUFA和汞浓度均高于中位数的受试者。有没有修改的风险APOE β 4 status.Conclusions：n-3多不饱和脂肪酸和痴呆症或AD之间没有关联被发现。汞的结果可能表明一个虚假的关联。美国临床营养杂志2009;90：184-92.
Background: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against dementia, although epidemiologic studies have yielded inconclusive results. Fish is the main dietary source of n-3 PUFAs and is sometimes contaminated with mercury. This neurotoxicant may modify the association with dementia.Objective: We evaluated the association of erythrocyte membrane total n-3 PUFAs, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and blood mercury with the incidence of dementia and Alzheimer disease (AD) in the Canadian Study of Health and Aging (CSHA) with adjustment for confounders including apolipoprotein E epsilon 4 ( APOE epsilon 4) status.Design: The CSHA is a cohort study of a representative sample of persons aged >= 65 y, conducted from 1991 to 2002. A subsample of 663 nondemented CSHA subjects with a complete clinical examination, blood samples, and follow-up information was eligible for prospective analyses on laboratory measurements. Of these, 149 were incident cases of dementia, including 105 with AD.Results: In adjusted Cox regression models with age as the time scale, there were no associations between total n-3 PUFAs, DHA, or EPA and dementia or AD. In contrast, a mercury concentration in the highest quartile was associated with a reduced risk of dementia (hazard ratio: 0.53; 95% CI: 0.33, 0.88). However, significant risk reductions were limited to subjects with concentrations of both n-3 PUFAs and mercury that were above the median. There was no modification of risk by APOE epsilon 4 status.Conclusions: No associations between n-3 PUFAs and dementia or AD were found. The results regarding mercury may indicate a spurious association. Am J Clin Nutr 2009;90:184-92.