Age-related differences in practice-dependent resting-state functional connectivity related to motor sequence learning
Age-related differences in practice-dependent resting-state functional connectivity related to motor sequence learning
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DOI：
10.1002/hbm.23428
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发表时间：
2017-02-01
影响因子：
4.8
通讯作者：
Peigneux, Philippe
中科院分区：
文献类型：
--
作者：
Mary, Alison;Wens, Vincent;Peigneux, Philippe
随着健康年龄的增长，被认为参与运动学习和记忆巩固过程的初级感觉运动(SM1)皮质的神经可塑性降低。本文研究了14名青年(19-30岁)和14名老年(66-70岁)健康受试者训练后静息状态功能连接性(RsFC)的重组及其与运动学习和早期巩固的关系。在行为层面上，参与者接受了运动序列学习任务的培训，然后在20-30分钟后重新测试短暂的脱机表现。使用基于感觉运动种子的方法，在学习之前和之后10分钟估计依赖于β频段功率包络相关的rsFC。训练后rsFC的变化(从学习前到学习后)与运动学习成绩和学习后一小时内脱机成绩的提高相关。年轻和老年参与者表现出不同的感觉运动相关rsFC模式，与运动学习和巩固具有特定的关系。我们的发现表明，学习后rsFC的变化反映了新运动技能的离线加工，并有助于学习后一小时内的早期记忆巩固。此外，年轻参与者和老年参与者在训练后rsFC变化的差异支持这样的假设，即年龄增长调节了新运动技能学习和随后早期巩固阶段的神经回路。Hum Brain Mapp 38：923-937,2017。(C)2016威利期刊公司。
Decreased neural plasticity is observed with healthy ageing in the primary sensorimotor (SM1) cortex thought to participate in motor learning and memory consolidation processes. In the present magnetoencephalography study, the post-training reorganization of resting-state functional connectivity (rsFC) and its relation with motor learning and early consolidation in 14 young (19-30 years) and 14 old (66-70 years) healthy participants were investigated. At the behavioral level, participants were trained on a motor sequence learning task then retested 20-30 min later for transient offline gains in performance. Using a sensorimotor seed-based approach, rsFC relying on beta band power envelope correlation was estimated immediately before and 10 min after the learning episode. Post-training changes in rsFC (from before to after learning) were correlated with motor learning performance and with the offline improvement in performance within the hour after learning. Young and old participants exhibited differential patterns of sensorimotor-related rsFC, bearing specific relationships with motor learning and consolidation. Our findings suggest that rsFC changes following learning reflect the offline processing of the new motor skill and contribute to the early memory consolidation within the hour after learning. Furthermore, differences in post-training changes in rsFC between young and old participants support the hypothesis that ageing modulates the neural circuits underlying the learning of a new motor skill and the early subsequent consolidation stages. Hum Brain Mapp 38:923-937, 2017. (c) 2016 Wiley Periodicals, Inc.