Using motivational interviewing to promote adherence to antiretroviral medications: A randomized controlled study
Using motivational interviewing to promote adherence to antiretroviral medications: A randomized controlled study
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DOI：
10.1080/09540120701593489
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发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
Lundberg, B.
中科院分区：
文献类型：
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作者：
DiIorio, C.;Mccarty, F.;Lundberg, B.
这项研究的主要目的是测试一种干预措施，以支持主要是低收入男性和女性艾滋病毒感染者的抗逆转录病毒药物治疗依从性。这项研究是一项随机对照试验（让忙碌生活），参与者被分配到治疗组（动机访谈[MI]）和对照组。参与者是从美国格鲁吉亚亚特兰大的一家艾滋病诊所招募的。在参与研究的患者中，247人完成了基线评估，125人随机分配到干预组，122人随机分配到对照组。参与者是开始抗逆转录病毒治疗或改用新药治疗的患者。干预包括五个MI会议提供注册护士在个人咨询会议。参加者每参加一次会议都得到报酬。该干预措施旨在建立信心，减少矛盾心理，增加服用抗逆转录病毒药物的动力。通过药物事件监测系统（MEMS）测量从筛选时至基线评估后约12个月进行的最终随访期间的药物依从性。在干预条件下的参与者显示出一种趋势，即在干预期后的几个月内，与对照组相比，处方剂量的平均百分比更高，按计划服用的剂量百分比更高。在研究期的第8个月左右开始观察到这种效应，并一直维持到研究的最后一个月。虽然服用处方剂量的总体百分比的结果较弱，但按计划服用剂量的百分比的结果表明，MI干预可能是解决药物依从性特定方面的有用方法，例如依从指定的给药方案。
The primary aim of this study was to test an intervention to support antiretroviral medication adherence among primarily low-income men and women with HIV. The study was a randomized controlled trial (Get Busy Living) with participants assigned to treatment (Motivational Interviewing [MI]) and control groups. Participants were recruited from an HIV/AIDS clinic in Atlanta, Georgia, US. Of those referred to the study, 247 completed a baseline assessment and were enrolled with 125 randomized to the intervention group and 122 to the control group. Participants were patients beginning antiretroviral therapy or changing to a new drug regimen. The intervention consisted of five MI sessions delivered by registered nurses in individual counselling sessions. Participants were paid for each session attended. The intervention sought to build confidence, reduce ambivalence and increase motivation for ART medication-taking. Medication adherence was measured by the Medication Event Monitoring System (MEMS) from the time of screening until the final follow-up conducted approximately 12 months following the baseline assessment. Participants in the intervention condition showed a trend towards having a higher mean percent of prescribed doses taken and a greater percent of doses taken on schedule when compared to the control group during the months following the intervention period. This effect was noted beginning at about the eighth month of the study period and was maintained until the final study month. Although the finding was weaker for overall percent of prescribed doses taken, the results for the percent of doses taken on schedule suggests that the MI intervention may be a useful approach for addressing specific aspects of medication adherence, such as adherrence to a specified dosing schedule.