Control of electrical alternans in canine cardiac purkinje fibers
Control of electrical alternans in canine cardiac purkinje fibers
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DOI：
10.1103/physrevlett.96.104101
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发表时间：
2006-03-17
影响因子：
8.6
通讯作者：
Gilmour, RF
中科院分区：
文献类型：
--
作者：
Christini, DJ;Riccio, ML;Gilmour, RF
连续心脏动作电位(电交替)持续时间的改变可能导致传导阻滞和心律失常的发生。因此，使用适当时机的早搏刺激抑制交替可能是抗心律失常的。为了确定在心脏组织中可以实现交替控制的程度，使用反馈控制方法从分离的犬浦肯野纤维的一端起搏。当交替信号的幅度较小时，交替信号的空间均匀控制是可能的。然而，随着交替波幅的增加，控制在空间上变得减弱。理论上与一维亥姆霍兹方程的第一个量子化模式相对应的驻波分布很好地描述了沿电缆的振幅变化。这些结果证实了交替波的波状性质，并可能对利用电刺激控制它们具有重要的意义。
Alternation in the duration of consecutive cardiac action potentials (electrical alternans) may precipitate conduction block and the onset of arrhythmias. Consequently, suppression of alternans using properly timed premature stimuli may be antiarrhythmic. To determine the extent to which alternans control can be achieved in cardiac tissue, isolated canine Purkinje fibers were paced from one end using a feedback control method. Spatially uniform control of alternans was possible when alternans amplitude was small. However, control became attenuated spatially as alternans amplitude increased. The amplitude variation along the cable was well described by a theoretically expected standing wave profile that corresponds to the first quantized mode of the one-dimensional Helmholtz equation. These results confirm the wavelike nature of alternans and may have important implications for their control using electrical stimuli.