Citalopram reduces social interaction in rats by activation of serotonin (5-HT)2C receptors
Citalopram reduces social interaction in rats by activation of serotonin (5-HT)2C receptors
复制标题
DOI：
10.1016/s0028-3908(99)00268-3
复制
发表时间：
2000-01-01
影响因子：
4.7
通讯作者：
Millan, MJ
中科院分区：
文献类型：
--
作者：
Dekeyne, A;Denorme, B;Millan, MJ
选择性5-羟色胺（5-HT）再摄取抑制剂（SSRI），西酞普兰（2.5 mg/kg，s.c.），减少大鼠的社会互动（SI）。5-HT_2B/2C受体拮抗剂SB_（206）553（0.63 mg/kg. s.c.），和5-HT 2C受体拮抗剂。SB242，084（0.04 mg/kg. i.p.），而5-HT 2A拮抗剂MDL 100，907（0.04 mg/kg，s.c.）5-HT 1A拮抗剂。WAY 100，635（0.16 mg/kg，s.c.），或5-HT 3拮抗剂昂丹司琼（0.16 mg/kg，s.c.）。这些数据表明，5-HT 2C受体参与西酞普兰的“致焦虑”作用。(C)2000爱思唯尔科技有限公司版权所有。
The selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, s.c.), reduced social interaction (SI) in rats. This action was abolished by the 5-HT2B/2C receptor antagonist, SB206,553 (0.63 mg/kg. s.c.), and the 5-HT2C receptor antagonist. SB242,084 (0.04 mg/kg. i.p.), but not by the 5-HT2A antagonist, MDL100,907 (0.04 mg/kg, s.c.), thc 5-HT1A antagonist. WAY100,635 (0.16 mg/kg, s.c.), or the 5-HT3 antagonist, ondansetron (0.16 mg/kg, s.c.). These data suggest that 5-HT2C receptors are involved in the "anxiogenic" actions of citalopram. (C) 2000 Elsevier Science Ltd. All rights reserved.