Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up
Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up
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DOI：
10.1016/s0015-0282(02)03323-x
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发表时间：
2002-11-01
影响因子：
6.7
通讯作者：
Devroey, P
中科院分区：
文献类型：
--
作者：
Kolibianakis, E;Bourgain, C;Devroey, P
目的：探讨重组FSH、GnRH拮抗剂和hCG刺激卵巢对卵母细胞提取当天子宫内膜成熟的影响。设计：前瞻性研究。单位：三级转诊中心。患者：55名接受体外受精/胞浆内单精子注射（ICSI）控制卵巢过度刺激的女性。干预：[1]重组FSH卵巢刺激，从周期的第2天开始，GnRH拮抗剂，在重组FSH刺激的中位数6天后开始（范围，5-12天）；[2] hCG诱导排卵；取卵时子宫内膜的[3]抽吸活检。主要观察指标：取卵时子宫内膜组织学符合Noyes标准。结果：在取卵时，所有拮抗剂周期均观察到子宫内膜成熟（2.5 +/- 0.1天）比预期时间提前。卵母细胞拾取时子宫内膜的推进与刺激开始时的LH值和拮抗剂开始前重组FSH治疗的持续时间一致。结论：刺激开始时LH值越高，拮抗剂开始前重组FSH治疗时间越长，取卵时子宫内膜成熟越早。(C) 2002年，美国生殖医学学会。
Objective: To assess the effect of ovarian stimulation with recombinant FSH, GnRH antagonists, and hCG on endometrial maturation on the day of oocyte pick-up.Design: Prospective study.Setting: Tertiary referral center.Patient(s): Fifty-five women undergoing controlled ovarian hyperstimulation for IVF/intracytoplasmic sperm injection (ICSI).Intervention(s): [1] Ovarian stimulation with recombinant FSH, starting on day 2 of the cycle and GnRH antagonist, starting after a median of 6 days of recombinant FSH stimulation (range, 5-12 days); [2] hCG administration for ovulation induction; and [3] aspirational biopsy of endometrium at oocyte pick-up.Main Outcome Measure(s): Endometrial histology at oocyte pick-up by Noyes criteria.Result(s): Advancement of endometrial maturation (2.5 +/- 0.1 days) as compared to the expected chronological date was observed in all antagonist cycles at oocyte retrieval. Endometrial advancement at oocyte pick-up increased in line with values of LH at initiation of stimulation and the duration of recombinant FSH treatment before the antagonist was started.Conclusion(s): The higher the values of LH at initiation of stimulation and the longer the duration of recombinant FSH treatment before the antagonist is started, the more advanced the endometrial maturation at oocyte pick-up. (C) 2002 by American Society for Reproductive Medicine.