New concepts about the mast cell.
New concepts about the mast cell.
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DOI：
10.1056/nejm199301283280408
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发表时间：
1993-01
期刊：
影响因子：
--
通讯作者：
S. Galli
中科院分区：
文献类型：
--
作者：
S. Galli
大多数内科医生和免疫学家，如果他们想到肥大细胞的话，会把它看作是一种贱民。造血来源的其他细胞，如中性粒细胞、巨噬细胞和血小板，在宿主防御、止血或两者中显然是重要的。相比之下，肥大细胞对病理状况的贡献比它在维持健康方面的任何作用更容易想到。事实上，有些人会争辩说，医学的一个完整的分支--过敏--在很大程度上涉及肥大细胞和嗜碱性粒细胞活化所产生的不良反应，例如。
Most physicians and immunologists, if they think of the mast cell at all, regard it as something of a pariah. Other cells of hematopoietic origin, such as neutrophils, macrophages, and platelets, are clearly important in host defense, hemostasis, or both. In contrast, the contributions of the mast cell to pathologic conditions come to mind much more readily than any role it may have in the maintenance of health. Indeed, some would argue that an entire branch of medicine -- allergy -- deals in large part with the adverse effects produced by activation of the mast cell and the basophil, a . . .