Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases.
Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases.
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一组儿科病例中与慢性疲劳综合征相关的危险因素。
DOI：
10.1093/clinids/13.supplement_1.s32
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
L. Cooper
中科院分区：
文献类型：
--
作者：
K. Bell;D. Cookfair;D. Bell;Peter P. Reese;L. Cooper
在纽约州北部的一个农业社区诊断出7例慢性疲劳综合征（CFS）的儿童病例后，向同一学区的所有学生分发了一份关于慢性疲劳综合征症状和潜在危险因素的问卷。21名学生有慢性疲劳综合症的症状。从问卷调查对象中随机抽取年龄和性别相匹配的两名对照者。通过电话验证所有受试者的健康状况，并由医生确认CFS的诊断。收集下列因素的资料：其他家庭成员是否有慢性疲劳综合症的症状；过敏/哮喘病史；食用生牛奶、生鸡蛋、生奶酪或生肉；供水;接触动物；家用供暖源；靠近农田/果园；蜱虫咬;输血;野营;和阑尾炎。logistic回归分析表明，最佳模型（以其他家庭成员的症状、最近摄入生牛奶和过敏/哮喘史为特征）产生了显著的相对风险估计(P小于。0.05)，分别为35.9、44.3和23.3（对其他协变量的影响进行了修正）。这些数据表明，宿主和环境因素的组合，包括一个或多个感染因子，参与了CFS的病因学。
After seven pediatric cases of chronic fatigue syndrome (CFS) were diagnosed in a farming community in upstate New York, a questionnaire regarding symptoms and potential risk factors of CFS was distributed to all students enrolled in the same school district. Twenty-one students with symptoms of CFS were identified. Two controls per case matched for age and sex were randomly selected from questionnaire respondents. Health status was verified for all subjects by telephone, and diagnosis of CFS was confirmed by a physician. Information was collected on the following factors: symptoms of CFS among other family members; history of allergy/asthma; consumption of raw milk, raw eggs, raw cheese, or raw meat; water supply; exposure to animals; home heating source; proximity to farmland/orchards; tick bite; blood transfusion; camping; and appendicitis. Logistic-regression analyses indicated that the best model (characterized by symptoms among other family members, recent ingestion of raw milk, and history of allergy/asthma) produced significant estimates of relative risk (P less than .05) of 35.9, 44.3, and 23.3, respectively, for the three factors (corrections were made for the effect of the other covariates). These data suggest that a combination of host and environmental factors, including an infectious agent or agents, are involved in the etiology of CFS.