Adipose tissue biomarkers of fatty acid intake
Adipose tissue biomarkers of fatty acid intake
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DOI：
10.1093/ajcn/76.4.750
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发表时间：
2002-10-01
影响因子：
7.1
通讯作者：
Campos, H
中科院分区：
文献类型：
--
作者：
Baylin, A;Kabagambe, EK;Campos, H
背景资料：生物标志物可以提供一个更准确的衡量长期摄入量比饮食questionnaire.Objective：目的是确定哪些脂肪组织脂肪酸是合适的生物标志物的摄入量进行评估与验证的食物频率问卷。设计：平均（+/- SD）年龄为56 +/- 11岁（n = 367）的哥斯达黎加男性和60 +/- 10岁（n = 136）的哥斯达黎加女性完成了135项食物频率问卷，并提供了脂肪组织样本。用毛细管气相色谱法鉴定了50种脂肪酸。校正年龄、性别、体重指数和吸烟状态后计算相关系数。结果：饱和脂肪酸总摄入量的最佳脂肪组织标志物为15：0 + 17：0（r = 0.18）。15：0和17：0也是乳制品摄入量的最佳相关系数（r = 0.31）。n-3脂肪酸的相关系数分别为：18：3 r = 0.34，20：5 r = 0.15，22：6 r = 0.18。膳食和脂肪组织n-6脂肪酸高度相关：18：2（r = 0.58）和18：3（r = 0.24）。总反式脂肪酸摄入量的最佳指标为ct 18：2n-6和tc 18：2n-6（r = 0.58）;总18：1反式脂肪酸（r = 0.45）和16：1反式脂肪酸（r = 0.16）为次优指标。脂肪组织是膳食脂肪酸摄入的合适生物标志物，特别是对于n-3和n-6顺式多不饱和脂肪酸和反式脂肪酸。理想地，在流行病学研究中，脂肪组织和饮食调查表应相互补充，而不是相互替代。
Background: Biomarkers can provide a more accurate measure of long-term intake than can dietary questionnaires.Objective: The objective was to identify which adipose tissue fatty acids are suitable biomarkers of intake as assessed with a validated food-frequency questionnaire.Design: Costa Rican men with a mean (+/- SD) age of 56 +/- 11 y (n = 367) and women aged 60 +/- 10 y (n = 136) completed a 135-item food-frequency questionnaire and provided art adipose tissue sample. Fifty fatty acids were identified by capillary gas chromatography. Correlation coefficients were calculated after adjustment for age, sex, body mass index, and smoking status.Results: The best adipose tissue marker for total intake of saturated fatty acids was 15:0 + 17:0 (r = 0.18). Both 15:0 and 17:0 were also the best correlates of dairy product intake (r = 0.31 for each). The diet-adipose tissue correlations for n-3 fatty acids were r = 0.34 for 18:3, r = 0.15 for 20:5, and r = 0.18 for 22:6, Fish intake correlated significantly with these adipose tissue n-3 fatty acids. Dietary and adipose tissue n-6 fatty acids were highly correlated: 18:2 (r = 0.58) and 18:3 (r = 0.24). The best indicators of total trans fatty acid intake were ct18:2n-6 and tc18:2n-6 (r = 0.58 for each); total 18:1 trans fatty acid (r = 0.45) and 16: 1 trans fatty acid (r = 0.16) were the next best indicators.Conclusions: Adipose tissue is a suitable biomarker of dietary fatty acid intake, particularly for n-3 and n-6 cis polyunsaturated fatty acids and trans fatty acids, Ideally, adipose tissue and dietary questionnaires should complement, rather than substitute for, each other in epidemiologic studies.