Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells.
Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells.
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DOI：
10.1136/jcp.2010.082156
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发表时间：
2010-12
影响因子：
3.4
通讯作者：
Terasaki H
中科院分区：
文献类型：
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作者：
Kubota T;Moritani S;Yoshino T;Nagai H;Terasaki H
目的报告眼附属器边缘区B细胞淋巴瘤(MZBL)的临床病理特点。对114例眼附属器MZBL的活检标本进行了分析。当Ig G4/Ig G比值为40%(Ig G4相关组)时，包括具有Ig G4阳性浆细胞的MZBL。将IgG4相关组和连续61例无IgG4阳性浆细胞的MZBL患者的血清免疫球蛋白和可溶性白介素2受体水平进行比较。并与10例眼附属器IgG4相关淋巴浆细胞性疾病患者(IgG4相关炎症组)进行比较。10例(9%)患者诊断为MZBLIgG4阳性浆细胞。与IgG4相关的MZBL中硬化度和反应性卵泡显著增加(p=0.0004.0 1和p=0.0 1)。IgG4相关组血清免疫球蛋白Ig G、Ig G1、Ig G4、Ig E和可溶性白介素2受体水平均显著高于Ig G4无关组(p=0.003，p=0.009，p=0.0001，p=0.0001和p=0.0007)。血清水平与IgG4相关炎症组无显著差异。与IgG4相关的组在复发病灶和胃中也有反应性的IgG4阳性淋巴浆细胞浸润。9%的眼附属器MZBL有IgG4阳性浆细胞渗入。提示眼附属器MZBLIgG4阳性浆细胞具有独特的组织学和血清学特征，与眼附属器IgG4相关淋巴浆细胞性浸润性疾病和全身疾病的特征相重叠。
To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) with IgG4-positive plasma cells. 114 biopsy samples of ocular adnexal MZBLs were analysed. MZBLs with IgG4-positive plasma cells were included when the IgG4:IgG ratio was >40% (IgG4-related group). The serum levels of each subclass of immunoglobulins and soluble interleukin-2 receptor in the IgG4-related group were compared with those in 61 consecutive patients having MZBL without IgG4-positive plasma cells (IgG4-unrelated group). They were also compared with those in 10 patients having ocular adnexal IgG4-related lymphoplasmacytic disorder (IgG4-related inflammatory group). Ten (9%) of the patients were diagnosed with MZBL with IgG4-positive plasma cells. The IgG4-related group had a significantly greater degree of sclerosis and reactive follicles in the MZBLs (p=0.0004 and p=0.01, respectively). The serum levels of IgG, IgG1, IgG4, IgE and soluble interleukin 2 receptor in the IgG4-related group were significantly higher than those in the IgG4-unrelated group (p=0.003, p=0.009, p<0.0001, p<0.0001 and p=0.0007, respectively). The serum levels did not differ significantly from those of the IgG4-related inflammatory group. The IgG4-related group also had reactive IgG4-positive lymphoplasmacytic infiltrations in the recurrent lesion and in the stomach. IgG4-positive plasma cells had infiltrated into ocular adnexal MZBLs in 9% of cases. It is suggested that ocular adnexal MZBLs with IgG4-positive plasma cells have unique histological and serological characteristics that overlap those of ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder and systemic conditions.
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影响因子：
--
作者：
Kubota, Toshinobu;Moritani, Suzuko;Terasaki, Hiroko
通讯作者：
Terasaki, Hiroko
影响因子：
5.6
作者：
Ferry, Judith A.;Fung, Claire Y.;Harris, Nancy L.
通讯作者：
Harris, Nancy L.
影响因子：
4.4
作者：
Genton, Celine;Wang, Ying;Acha-Orbea, Hans
通讯作者：
Acha-Orbea, Hans
影响因子：
4.2
作者：
Kubota, Toshinobu;Moritani, Suzuko;Terasaki, Hiroko
通讯作者：
Terasaki, Hiroko
影响因子：
5.6
作者：
Cheuk, Wah;Yuen, Hunter K. L.;Chan, John K. C.
通讯作者：
Chan, John K. C.