Kinetics of charge separation in poly(A)-poly(T) DNA hairpins.
Kinetics of charge separation in poly(A)-poly(T) DNA hairpins.
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Poly(A)-poly(T) DNA 发夹中电荷分离的动力学。
DOI：
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发表时间：
2010
影响因子：
3.3
通讯作者：
A. Burin
中科院分区：
文献类型：
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作者：
G. Blaustein;F. Lewis;A. Burin
设计了一个动力学模型来研究由AT碱基对组成的二苯乙烯帽DNA发夹的电荷分离过程。该模型结合了标准的隧穿和跳跃电子传递以及受体二苯乙烯及其邻近腺嘌呤在光激发下形成的杂化，能够在实验精度范围内解释CT率和产率数据。在一维扩散模型的框架内对跳变输运进行分析，计算出最近邻CT速率约为1.2 ns（-1）。与以往的实验和理论工作一致，通过对经典Marcus理论的扩展，确定了最近邻CT是绝热的，重组能λ约为0.83 eV。该动力学模型可以扩展到具有不同孔洞供体（萘二亚胺和2-氨基嘌呤）和受体（吩噻嗪和鸟嘌呤）的其他聚(A)-聚(T)体系中的CT准确表征。
A kinetics model is designed to investigate the charge separation (CT) process in stilbene-capped DNA hairpins composed of AT base pairs. This model combines standard tunneling and hopping electron transport with exciplex formation upon photoexcitation of the acceptor stilbene and its neighboring adenine and is capable of interpreting the CT rate and yield data within experimental accuracy. An analysis of hopping transport within the framework of a 1-D diffusion model results in a calculation of the nearest-neighbor CT rate to be approximately 1.2 ns(-1). In agreement with previous experimental and theoretical work, it is ascertained through a novel application of an extension to classical Marcus theory that the nearest-neighbor CT is adiabatic with reorganization energy lambda approximately 0.83 eV. The kinetics model can be extended to accurately characterize CT in other poly(A)-poly(T) systems with different hole donors (naphthaldiimide and 2-aminopurine) and acceptors (phenothiazine and guanine).