Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction
Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction
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DOI：
10.1007/s10856-011-4253-3
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发表时间：
2011-04-01
影响因子：
3.7
通讯作者：
Engqvist, Hakan
中科院分区：
文献类型：
--
作者：
Grandfield, Kathryn;Palmquist, Anders;Engqvist, Hakan
本研究评价了游离形式制造的钴铬合金（CoCr）植入物（带和不带羟基磷灰石（HA）等离子喷涂涂层）的体内反应。自由成形制造方法允许在圆柱形植入物上集成复杂的锥形表面结构。将植入物压配到9只新西兰白色家兔的胫骨干骺端中。处死动物，取出植入物并包埋。进行组织学分析、组织形态计量学和电子显微镜研究。聚焦离子束用于制备用于高分辨率透射电子显微镜检查的薄切片。6周后，制造的特征允许有效的骨向内生长和牢固固定。透射电子显微镜调查显示，在纳米级的HA涂层样品密切的骨植入物整合。此外，组织形态测定显示HA涂层种植体的骨接触显著高于天然CoCr种植体。得出的结论是，在实验条件下，结合HA涂层的自由成形制造改善了骨中的早期固定。
The current study evaluates the in vivo response to free form fabricated cobalt chromium (CoCr) implants with and without hydroxyapatite (HA) plasma sprayed coatings. The free form fabrication method allowed for integration of complicated pyramidal surface structures on the cylindrical implant. Implants were press fit into the tibial metaphysis of nine New Zealand white rabbits. Animals were sacrificed and implants were removed and embedded. Histological analysis, histomorphometry and electron microscopy studies were performed. Focused ion beam was used to prepare thin sections for high-resolution transmission electron microscopy examination. The fabricated features allowed for effective bone in-growth and firm fixation after 6 weeks. Transmission electron microscopy investigations revealed intimate bone-implant integration at the nanometre scale for the HA coated samples. In addition, histomorphometry revealed a significantly higher bone contact on HA coated implants compared to native CoCr implants. It is concluded that free form fabrication in combination with HA coating improves the early fixation in bone under experimental conditions.