Humanized Mice as a Tool to Study Sepsis-More Than Meets the Eye.
Humanized Mice as a Tool to Study Sepsis-More Than Meets the Eye.
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DOI：
10.3390/ijms22052403
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发表时间：
2021-02-27
影响因子：
5.6
通讯作者：
Laudanski K
中科院分区：
文献类型：
--
作者：
Laudanski K
(1) 背景。重复的动物研究在转化为临床疗法时令人失望，这导致人们越来越重视人源化小鼠作为针对啮齿动物模型缺点的补救措施。然而，必须深入了解它们的局限性。 (2)方法。这是对人源化小鼠和败血症文献的叙述性全面回顾，以了解该模型的优点和缺点。 (3) 结果：涉及脓毒症人源化模型的研究包括细菌、病毒和原生动物病因学。人源化小鼠为脓毒症的病因学和自然史提供了一些独特的见解，对于研究埃博拉病毒以及某些病毒和原生动物感染特别有用。然而，研究相对较少，并且基于几种不同的脓毒症模型和人源化动物。 (4)结论。利用人源化小鼠作为脓毒症模型存在复杂的局限性，一旦克服这些限制，将为脓毒症病因学和治疗的进步带来一些潜力。
(1) Background. Repetitive animal studies that have disappointed upon translation into clinical therapies have led to an increased appreciation of humanized mice as a remedy to the shortcomings of rodent-based models. However, their limitations have to be understood in depth. (2) Methods. This is a narrative, comprehensive review of humanized mice and sepsis literature to understand the model’s benefits and shortcomings. (3) Results: Studies involving humanized models of sepsis include bacterial, viral, and protozoan etiology. Humanized mice provided several unique insights into the etiology and natural history of sepsis and are particularly useful in studying Ebola, and certain viral and protozoan infections. However, studies are relatively sparse and based on several different models of sepsis and humanized animals. (4) Conclusions. The utilization of humanized mice as a model for sepsis presents complex limitations that, once surpassed, hold some potential for the advancement of sepsis etiology and treatment.
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影响因子：
3.1
作者：
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