Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones
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DOI：
10.1006/bbrc.2000.3087
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发表时间：
2000-07-21
影响因子：
3.1
通讯作者：
Segura-Aguilar, J
中科院分区：
文献类型：
--
作者：
Dagnino-Subiabre, A;Cassels, BK;Segura-Aguilar, J
Human glutathione transferase M2-2 prevents the formation of neurotoxic aminochrome and dopachrome by catalyzing the conjugation of dopamine and dopa o-quinone with glutathione. NMR analysis of dopamine and dopa o-quinone-glutathione conjugates revealed that the addition of glutathione was at C-5 to form 5-S-glutathionyl-dopamine and 5-S-glutathionyldopa, respectively. Both conjugates were found to be resistant to oxidation by biological oxidizing agents such as O-2, H2O2, and O-2(.-), and the glutathione transferase-catalyzed reaction can therefore serve a neuroprotective antioxidant function. (C) 2000 Academic Press.
