A novel antimycin-like compound, JBIR-06, from Streptomyces sp ML55
A novel antimycin-like compound, JBIR-06, from Streptomyces sp ML55
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DOI：
10.1038/ja.2008.35
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发表时间：
2008-04-01
影响因子：
3.3
通讯作者：
Shin-ya, Kazuo
中科院分区：
文献类型：
--
作者：
Ueda, Jun-ya;Nagai, Aya;Shin-ya, Kazuo
从链霉菌（Streptomyces sp. ML55）中分离到一个新的抗霉素家族化合物JBIR-06(1)。根据光谱数据，确定了1的结构为与3-（甲酰基胺）-2-羟基苯甲酰胺组成的12元大环骨架。化合物1抑制2-脱氧葡萄糖诱导的GRP78的表达，IC50值为250 nM。
A novel compound of antimycin family, JBIR-06 (1), was isolated from Streptomyces sp. ML55. The structure of 1 was established as a twelve-membered macrocyclic skeleton with a 3-(formylamino)-2-hydroxybenzamide based on the spectroscopic data. Compound I inhibited the expression of GRP78 induced by 2-deoxyglucose at the IC50 value of 250 nM.