CUTting genetic noise by polyadenylation-induced RNA degradation
CUTting genetic noise by polyadenylation-induced RNA degradation
复制标题
DOI：
10.1016/j.tcb.2005.10.004
复制
发表时间：
2005-12-01
影响因子：
19
通讯作者：
Chanfreau, GF
中科院分区：
文献类型：
--
作者：
Chanfreau, GF
真核生物基因组区域的沉默被认为是转录抑制的结果。最近的研究结果表明，核RNA降解在丢弃RNA分子中起着重要作用，而在整个酿酒酵母基因组中由隐蔽RNA聚合酶II转录产生的RNA分子没有明显的作用。这些隐藏的转录物在其3 '端被聚腺苷酸聚合酶复合物聚腺苷酸化，该聚合酶复合物不同于mRNA工厂所使用的聚合酶复合物，其用于标记这些异常转录物以进行核降解。
Silencing of genomic regions in eukaryotes is thought to be the result of transcriptional repression. Recent results show that nuclear RNA degradation plays a major role in discarding RNA molecules with no obvious roles that are produced by cryptic RNA polymerase II transcription throughout the Saccharomyces cerevisiae genome. These cryptic transcripts are polyadenylated at their 3'-end by a poly(A) polymerase complex distinct from that used by the mRNA factory, which serves to tag these aberrant transcripts for nuclear degradation.