Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction.
Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction.
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DOI：
10.1254/jphs.sc0040167
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发表时间：
2005
影响因子：
3.5
通讯作者：
Hideo Takahashi;H. Iwagaki;R. Tamura;T. Yagi;T. Yoshino;S. Mori;N. Tanaka;M. Nishibori
中科院分区：
文献类型：
--
作者：
Hideo Takahashi;H. Iwagaki;R. Tamura;T. Yagi;T. Yoshino;S. Mori;N. Tanaka;M. Nishibori
器官移植后急性排斥反应期间血浆中白细胞介素（IL）-18水平升高。在人类混合淋巴细胞反应（急性排斥反应的体外模型）中，IL-18 会引发粘附分子表达以及干扰素-γ/IL-12 产生和 T 细胞增殖。我们检查了针对细胞间粘附分子 (ICAM)-1、B7、CD40 和 CD40、配体 (CD40L) 的抗体 (Ab) 是否影响细胞因子的产生和 T 细胞增殖。抗 ICAM-1 和 B7 抗体抑制细胞因子的产生，而所有抗体均抑制 T 细胞增殖。 ICAM-1和B7以及CD40可能在急性排斥反应中发挥不同的作用。
The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-gamma/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and B7 Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.