Synthesizing mammogram from digital breast tomosynthesis.
Synthesizing mammogram from digital breast tomosynthesis.
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从数字乳房断层合成合成乳房X线照片。
DOI：
10.1088/1361-6560/aafcda
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发表时间：
2019
影响因子：
3.5
通讯作者：
Zhou,Chuan
中科院分区：
文献类型：
--
作者：
Wei,Jun;Chan,Heang-Ping;Helvie,MarkA;Roubidoux,MarilynA;Neal,ColleenH;Lu,Yao;Hadjiiski,LubomirM;Zhou,Chuan
本研究的目的是开发一种从数字乳房断层合成 (DBT) 生成合成乳房 X 光照片 (SM) 的新方法，并评估其作为 DBT 辅助手段的潜力。我们首先对重建的 DBT 切片应用多尺度双边滤波，以增强高频特征并减少噪声。然后从 DBT 切片的高频分量获得最大强度投影 (MIP) 图像。设计了一种多尺度图像融合方法，将MIP图像和中心DBT投影视图合并成SM，并进一步增强高频特征。我们进行了一项试点读者研究，以目视评估 SM 与全视野数字乳房 X 光检查 (FFDM) 的图像质量。对于每个 DBT 头尾或内侧视图，回顾性收集相应视图的临床 FFDM。三名 MQSA 放射科医生对病理和其他临床信息不知情，独立解释了 SM 和并排标记有病变位置的相应 FFDM。对于所有三位读者来说，SM 和 FFDM 之间 MC 和肿块的 BI-RADS 评估差异并未达到统计显着性。 SM 上 MC 的显着性优于 FFDM，并且 MC 的 BI-RADS 评估具有可比性，而 SM 上肿块的显着性下降，SM 上的解释不如 FFDM 上准确。 SM 对于 DBT 中 MC 的有效预筛选可能很有用，但 DBT 应该用于质量的检测和表征。
The purpose of this study is to develop a new method for generating synthesized mammogram (SM) from digital breast tomosynthesis (DBT) and to assess its potential as an adjunct to DBT. We first applied multiscale bilateral filtering to the reconstructed DBT slices to enhance the high-frequency features and reduce noise. A maximum intensity projection (MIP) image was then obtained from the high-frequency components of the DBT slices. A multiscale image fusion method was designed to combine the MIP image and the central DBT projection view into an SM and further enhance the high-frequency features. We conducted a pilot reader study to visually assess the image quality of SM in comparison to full field digital mammograms (FFDM). For each DBT craniocaudal or mediolateral view, a clinical FFDM of the corresponding view was retrospectively collected. Three MQSA radiologists, blinded to the pathological and other clinical information, independently interpreted the SM and the corresponding FFDM side by side marked with the lesion locations. The differences in the BI-RADS assessments of both MCs and masses between SM and FFDM did not achieve statistical significance for all three readers. The conspicuity of MCs on SM was superior to that on FFDM and the BI-RADS assessments of MCs were comparable while the conspicuity of masses on SM was degraded and interpretation on SM was less accurate than that on FFDM. The SM may be useful for efficient prescreening of MCs in DBT but the DBT should be used for detection and characterization of masses.