Whole-Body MRI, Including Diffusion-Weighted Imaging, for Staging Lymphoma: Comparison With CT in a Prospective Multicenter Study
Whole-Body MRI, Including Diffusion-Weighted Imaging, for Staging Lymphoma: Comparison With CT in a Prospective Multicenter Study
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DOI：
10.1002/jmri.24356
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发表时间：
2014-07-01
影响因子：
4.4
通讯作者：
Nievelstein, Rutger A. J.
中科院分区：
文献类型：
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作者：
Kwee, Thomas C.;Vermoolen, Malou A.;Nievelstein, Rutger A. J.
目的：比较全身磁共振成像（MRI），包括扩散加权成像（DWI），计算机断层扫描（CT）分期新诊断lymphoma.Materials and Methods：在所有，108例新诊断的淋巴瘤前瞻性地进行了全身MRI（T1加权和T2加权短反转时间反转恢复[n = 108]，和DWI [n = 104]）和CT。根据全身MRI和CT结果进行安阿伯分期。通过骨髓活检、FDG-PET和随访研究解决了分期分歧。结果：无DWI的全身MRI分期结果与CT相同者占66.6%，高于CT者占24.1%，低于CT者占9.3%，其中正确/错误/未分辨的高分期者占15/7/4例，错误/未分辨的低分期者占9/1例。65.4%的全身MRI DWI分期结果与CT相同，27.9%高于CT，6.7%低于CT，其中18/6/5例患者的正确/不正确/未解决的分期高于CT，6/1例患者的不正确/未解决的分期低于CT。本研究的结果表明，在大多数新诊断的淋巴瘤患者中，全身MRI分期等于CT分期。未证实额外DWI的优势。如果应避免辐射暴露，全身MRI可能是CT的良好替代方案。
Purpose: To compare whole-body magnetic resonance imaging (MRI), including diffusion-weighted imaging (DWI), to computed tomography (CT) for staging newly diagnosed lymphoma.Materials and Methods: In all, 108 patients with newly diagnosed lymphoma prospectively underwent whole-body MRI (T1-weighted and T2-weighted short inversion time inversion recovery [n = 108], and DWI [n = 104]) and CT. Ann Arbor stages were assigned according to whole-body MRI and CT findings. Staging disagreements were resolved using bone marrow biopsy, FDG-PET, and follow-up studies. The results were descriptively analyzed.Results: Staging results of whole-body MRI without DWI were equal to those of CT in 66.6%, higher in 24.1%, and lower in 9.3%, with correct/incorrect/unresolved higher staging and incorrect/unresolved lower staging relative to CT in 15/7/4 and 9/1 patient(s), respectively. Staging results of whole-body MRI with DWI were equal to those of CT in 65.4%, higher in 27.9%, and lower in 6.7%, with correct/incorrect/unresolved higher staging and incorrect/unresolved lower staging relative to CT in 18/6/5 and 6/1 patient(s), respectively.Conclusion: The results of this study suggest that whole-body MRI staging equals CT staging in the majority of patients with newly diagnosed lymphoma. No advantage of additional DWI was demonstrated. Whole-body MRI can be a good alternative to CT if radiation exposure should be avoided.