Role of Platelets in Detection and Regulation of Infection.
Role of Platelets in Detection and Regulation of Infection.
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DOI：
10.1161/atvbaha.120.314645
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Campbell RA
中科院分区：
文献类型：
--
作者：
Portier I;Campbell RA
血小板是止血和血栓形成的基本介质。然而，近年来，血小板因其在感染性疾病期间调节免疫反应的炎症功能而获得认可。血小板含有各种免疫受体，使它们能够作为哨兵识别血管内病原体。在活化后，血小板通过释放抗微生物肽直接限制病原体生长，并通过活化免疫细胞确保病原体清除。然而，异常的血小板活化可导致炎症和血栓形成事件。
Platelets are classically known as essential mediators of hemostasis and thrombosis. However, in recent years, platelets have gained recognition for their inflammatory functions which modulate the immune response during infectious diseases. Platelets contain various immunoreceptors that enable them to act as sentinels to recognize intravascular pathogens. Upon activation, platelets directly limit pathogen growth through the release of antimicrobial peptides and ensure pathogen clearance through activation of immune cells. However, aberrant platelet activation can lead to inflammation and thrombotic events.