A NON-TRANSFERRIN-BOUND SERUM IRON IN IDIOPATHIC HEMOCHROMATOSIS
A NON-TRANSFERRIN-BOUND SERUM IRON IN IDIOPATHIC HEMOCHROMATOSIS
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DOI：
10.1007/bf01308057
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发表时间：
1980-01-01
影响因子：
3.1
通讯作者：
SHERLOCK, S
中科院分区：
文献类型：
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作者：
BATEY, RG;FONG, PLC;SHERLOCK, S
用同位素标记方法研究了特发性血色沉着症患者血清中铁的性质，并与正常人和其他形式的肝病患者的结果进行了比较。添加到正常血清中的示踪剂59Fe的2%至4%被DEAE Sephadex保留，并已被指定为非转铁蛋白结合。酒精性肝病、慢性活动性肝炎和缺铁对这一比例没有影响。在特发性血色沉着症中，34.6±3.9%的添加铁在诊断时未与转铁蛋白结合，相当于每升血清约700μg铁。在血清铁浓度降至正常之前，治疗会降低这一比例。大多数非转铁蛋白结合的铁是低分子的，不与白蛋白结合。这一组分的存在可能对组织含铁血黄素沉着症的发展有重要作用。
The nature of iron in the serum of patients with idiopathic hemochromatosis has been studied utilizing an isotope labeling method and results have been compared with those from normal individuals and patients with other forms of liver disease. Between 2 and 4% of a tracer dose of59Fe added to normal serum was retained by DEAE Sephadex and has been designated non-transferrin-bound. Alcoholic liver disease, chronic active hepatitis, and iron deficiency have no effect on this fraction. In idiopathic hemochromatosis 34.6±3.9% of the added iron was not bound to transferrin at diagnosis, representing approximately 700 μg Fe/liter serum. Treatment lowers this fraction before serum iron concentration falls to normal. The majority of the non-transferrin-bound iron is of low molecular weight and is not bound to albumin. The presence of this fraction may contribute significantly to the development of tissue siderosis.