Botanical ingredient identification and quality assessment: strengths and limitations of analytical techniques
Botanical ingredient identification and quality assessment: strengths and limitations of analytical techniques
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DOI：
10.1007/s11101-019-09625-z
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发表时间：
2020-10-01
影响因子：
7.7
通讯作者：
Glasl, Sabine
中科院分区：
文献类型：
--
作者：
Upton, Roy;David, Bruno;Glasl, Sabine
全球对植物药的兴趣日益浓厚，目前全球市场价值估计超过 720 亿美元。为了确保植物制剂中使用的成分得到适当识别，并在发挥预期功效的同时最大限度地降低潜在风险，需要良好生产规范 (GMP)。 GMP 要求使用科学有效的分析技术。本综述讨论了各种质量评估技术，考虑到院士和制造商之间的不同挑战，基本前提是，如果使用得当，所有技术都是科学有效的，反之，如果不以科学有效的方式使用，所有技术都会受到限制。将讨论其中一些技术的优点和局限性、应用和不适用，以及传统和更现代的分析技术之间的差异。重点强调经典植物学和传统宏观形态评估技术，这些技术代表了分析化学和遗传学等其他技术上游鉴定和质量评估的基础。事实证明，一套植物和化学技术为确保植物药的特性和质量提供了最大的信心。
Interest in botanical medicines is increasing worldwide with current global market values estimated to be greater than US $72 billion. To ensure ingredients used in botanical preparations are appropriately identified and will deliver the intended benefit while minimizing potential for risk, good manufacturing practices (GMPs) are required. GMPs require that scientifically valid analytical techniques be used. This review discusses a variety of techniques of quality assessment taking into account the different challenges between academicians and manufacturers with the basic premise that all techniques are scientifically valid if used appropriately, and conversely, are limited if not used in a scientifically valid manner. The strengths and limitations, applications and inapplicability, of some of these techniques will be discussed, as will differences between traditional and more modern analytical techniques. A strong emphasis is placed on classical botanical and traditional macromorphological assessment techniques that represent the basis of identification and quality assessment upstream of other techniques such as analytical chemistry and genetics. It will be shown that it is the suite of botanical and chemical techniques that provides the greatest confidence for ensuring the identity and quality of botanical medicines.