REPAIR OF THE ULTRAVIOLET-IRRADIATED MALE GENOME IN FERTILIZED MOUSE EGGS
REPAIR OF THE ULTRAVIOLET-IRRADIATED MALE GENOME IN FERTILIZED MOUSE EGGS
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DOI：
10.1126/science.7466400
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
PEDERSEN, RA
中科院分区：
文献类型：
--
作者：
BRANDRIFF, B;PEDERSEN, RA
在小鼠受精卵的雄性和雌性原核中发生非程序性DNA合成，以响应紫外线照射，表明切除修复的能力。受精前雄配子DNA的损伤可以在精子进入卵细胞质后修复。
Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with UV light, indicating a capacity for excision repair. Damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.