Neural stem cell therapy for cancer.
Neural stem cell therapy for cancer.
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DOI：
10.1016/j.ymeth.2015.08.013
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发表时间：
2016-04-15
期刊：
影响因子：
--
通讯作者：
Hingtgen SD
中科院分区：
文献类型：
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作者：
Bagó JR;Sheets KT;Hingtgen SD
脑癌仍然是最大的医学挑战之一。传统的手术和放化疗无法根除弥漫性癌细胞，肿瘤复发几乎不可避免。与传统的再生医学应用相比，工程神经干细胞（NSCs）正在成为一种有前景的癌症治疗新策略。肿瘤归巢特性允许NSCs进入原发性和侵袭性肿瘤病灶，创造了一个新的传递平台。在临床前模型中，用多种细胞毒性药物修饰的NSCs可以显著减少肿瘤体积并显著延长生存期。随着最近新的临床试验的启动，细胞毒性NSC治疗在人类患者中成功管理癌症的潜力正在接近成为现实。
Cancers of the brain remain one of the greatest medical challenges. Traditional surgery and chemoradiation therapy are unable to eradicate diffuse cancer cells and tumor recurrence is nearly inevitable. In contrast to traditional regenerative medicine applications, engineered neural stem cells (NSCs) are emerging as a promising new therapeutic strategy for cancer therapy. The tumor-homing properties allow NSCs to access both primary and invasive tumor foci, creating a novel delivery platform. NSCs engineered with a wide array of cytotoxic agents have been found to significantly reduce tumor volumes and markedly extend survival in preclinical models. With the recent launch of new clinical trials, the potential to successfully manage cancer in human patients with cytotoxic NSC therapy is moving closer to becoming a reality.