Susceptibility of SARS-CoV-2 to UV irradiation.
Susceptibility of SARS-CoV-2 to UV irradiation.
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DOI：
10.1016/j.ajic.2020.07.031
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发表时间：
2020-10-01
影响因子：
4.9
通讯作者：
Krawczyk, Adalbert
中科院分区：
文献类型：
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作者：
Heilingloh, Christiane Silke;Aufderhorst, Ulrich Wilhelm;Krawczyk, Adalbert
冠状病毒SARS-CoV-2大流行成为全球健康负担。我们测定了SARS-CoV-2对紫外线照射的敏感性。这种病毒对紫外线非常敏感。暴露9分钟后，通过UVC照射完全灭活具有5 * 106 TCID 50/mL的高感染性滴度的病毒原液。完全灭活所需的UVC剂量为1，048 mJ/cm 2。UVA暴露在15分钟内仅表现出对病毒灭活的微弱影响。因此，通过UVC照射灭活SARS-CoV-2构成了用于卫生保健设施消毒目的和制备用于研究目的的SARS-CoV-2材料的可靠方法。
The coronavirus SARS-CoV-2 pandemic became a global health burden. We determined the susceptibility of SARS-CoV-2 to irradiation with ultraviolet light. The virus was highly susceptible to ultraviolet light. A viral stock with a high infectious titer of 5 * 106TCID50/mL was completely inactivated by UVC irradiation after nine minutes of exposure. The UVC dose required for complete inactivation was 1,048 mJ/cm2. UVA exposure demonstrated only a weak effect on virus inactivation over 15 minutes. Hence, inactivation of SARS-CoV-2 by UVC irradiation constitutes a reliable method for disinfection purposes in health care facilities and for preparing SARS-CoV-2 material for research purpose.