Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation.
Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation.
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混合囊泡可实现机械响应水凝胶降解。
DOI：
10.1002/anie.202308509
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Liu,AllenP
中科院分区：
文献类型：
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作者：
Hwang,Sung-Won;Lim,Chung-Man;Huynh,CongTruc;Moghimianavval,Hossein;Kotov,NicholasA;Alsberg,Eben;Liu,AllenP
刺激响应水凝胶是有趣的仿生材料。以前开发机械响应水凝胶的努力主要依赖于水凝胶结构的化学修饰。在这里，我们提出了一种简单的、可推广的策略，赋予水凝胶机械响应行为。我们的方法包括将由磷脂和两亲性嵌段共聚物组成的混合囊泡嵌入水凝胶基质中，充当信号传感器。在机械应力下，这些囊泡发生变形和破裂，释放出可以控制水凝胶网络的封装化合物。为了证明这一概念，我们将含有乙二醇四乙酸（EGTA）（一种钙螯合剂）的囊泡嵌入钙交联的藻酸盐水凝胶中。压缩时，释放的 EGTA 会螯合钙离子并降解水凝胶。这项研究提供了一种设计机械响应水凝胶的新方法，可用于各种生物医学应用。
Stimuli‐responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano‐responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable strategy that confers mechano‐responsive behavior on hydrogels. Our approach involves embedding hybrid vesicles, composed of phospholipids and amphiphilic block copolymers, within the hydrogel matrix to act as signal transducers. Under mechanical stress, these vesicles undergo deformation and rupture, releasing encapsulated compounds that can control the hydrogel network. To demonstrate this concept, we embedded vesicles containing ethylene glycol tetraacetic acid (EGTA), a calcium chelator, into a calcium‐crosslinked alginate hydrogel. When compressed, the released EGTA sequesters calcium ions and degrades the hydrogel. This study provides a novel method for engineering mechano‐responsive hydrogels that may be useful in various biomedical applications.