Responses to auditory stimuli in macaque lateral intraparietal area II. Behavioral modulation
Responses to auditory stimuli in macaque lateral intraparietal area II. Behavioral modulation
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DOI：
10.1152/jn.1999.82.1.343
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发表时间：
1999-07-01
影响因子：
2.5
通讯作者：
Andersen, RA
中科院分区：
文献类型：
--
作者：
Linden, JF;Grunewald, A;Andersen, RA
外侧顶内区（LIP）是后顶叶皮层的一个区域，曾被认为对听觉刺激无反应。然而，最近的报告表明，在听觉刺激的视觉扫视任务中，LIP区的神经元。LIP区的听觉反应在多大程度上依赖于快速扫视任务的表现？为了解决这个问题，在两只猴子进行听觉和视觉记忆扫视和固定任务时，记录了两只猴子的160个LIP神经元。听觉刺激的反应显着更强的记忆眼跳任务比在固定任务，而视觉刺激的反应没有。此外，神经元对听觉刺激的反应也往往是视觉上的反应，并表现出延迟或眼跳活动的记忆眼跳任务。这些结果表明，在一般情况下，在LIP区的听觉反应调制的行为背景下，与视觉反应，并预测延迟或眼跳活动。因此，对LIP区听觉刺激的反应最好解释为超模态反应，在性质上与延迟活动相似，而不是模态特异性感觉反应。听觉活动和眼动行为之间的明显联系表明，LIP区对听觉刺激的反应的行为调制反映了听觉刺激作为眼动目标的选择。
The lateral intraparietal area (LIP), a region of posterior parietal cortex, was once thought to be unresponsive to auditory stimulation. However, recent reports have indicated that neurons in area LIP respond to auditory stimuli during an auditory-saccade task. To what extent are auditory responses in area LIP dependent on the performance of an auditory-saccade task? To address this question, recordings were made from 160 LIP neurons in two monkeys while the animals performed auditory and visual memory-saccade and fixation tasks. Responses to auditory stimuli were significantly stronger during the memory-saccade task than during the fixation task, whereas responses to visual stimuli were not. Moreover, neurons responsive to auditory stimuli tended also to be visually responsive and to exhibit delay or saccade activity in the memory-saccade task. These results indicate that, in general, auditory responses in area LIP are modulated by behavioral context, are associated with visual responses, and are predictive of delay or saccade activity. Responses to auditory stimuli in area LIP may therefore be best interpreted as supramodal responses, and similar in nature to the delay activity, rather than as modality-specific sensory responses. The apparent link between auditory activity and oculomotor behavior suggests that the behavioral modulation of responses to auditory stimuli in area LIP reflects the selection of auditory stimuli as targets for eye movements.