High frequency of mutator phenotype in human prostatic adenocarcinoma.
High frequency of mutator phenotype in human prostatic adenocarcinoma.
复制标题
人类前列腺腺癌中突变表型的频率很高。
作者：
Xiang Gao;N. Wu;D. Grignon;A. Zacharek;H. Liu;A. Salkowski;Gangyong Li;W. Sakr;F. Sarkar;A. Porter;Yong Q. Chen;K. Honn
核苷酸重复序列的突变表型与人类癌症和其他疾病有关。这种不稳定性可能是DNA复制和/或修复错误的直接结果。为了研究人类前列腺癌发展过程中的突变子表型，我们对57例前列腺癌患者进行了12条染色体（3p、5q、6p、7p、8p、10q、11p、13q、16q、17p、18q和Xq）上18个微卫星标记位点的可能突变子表型筛选。总的来说，在57例患者中的37例中，我们在分析的至少一个基因座中发现了阳性突变表型。在低分化的前列腺腺癌中，这种表型阳性的病例明显多于中分化和高分化的前列腺腺癌。我们的数据表明，突变表型可能在人类前列腺癌的发生和发展中发挥重要作用。
Mutator phenotype of nucleotide repeats has been implicated to be involved in human cancer and other diseases. This type of instability may be the direct result of DNA replication and/or repair errors. To examine mutator phenotype during the development of human prostate cancer, we undertook this study to screen 57 patients with prostatic adenocarcinoma for possible mutator phenotype at 18 microsatellite marker loci on 12 chromosomes (3p, 5q, 6p, 7p, 8p, 10q, 11p, 13q, 16q, 17p, 18q and Xq). Overall, in 37 of 57 patients, we have found positive mutator phenotype in at least one of the loci analysed. A significantly greater number of cases were found to be positive for this phenotype among the poorly differentiated than the moderately- and well-differentiated prostatic adenocarcinomas. Our data suggest that mutator phenotype may play an important role in the development and progression of human prostate cancer.