Prior history of allergies and pancreatic cancer in the San Francisco Bay Area
Prior history of allergies and pancreatic cancer in the San Francisco Bay Area
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DOI：
10.1093/aje/kwg174
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发表时间：
2003-09-01
影响因子：
5
通讯作者：
Bracci, PM
中科院分区：
文献类型：
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作者：
Holly, EA;Eberle, CA;Bracci, PM
对1994年至2001年在旧金山弗朗西斯科湾区进行的一项基于人群的病例对照研究的数据进行分析，以检查胰腺癌与过敏性疾病史之间的关系。胰腺癌病例（n=532）的年龄必须在21-85岁之间，并使用快速病例确定进行识别。随机数字拨号和卫生保健财务管理局名单（年龄，大于或等于65岁），以获得1,701名对照谁是频率匹配的病例按性别和年龄在5年内。进行了面对面访谈，并获得了所有参与者的详细过敏史数据。任何过敏史与胰腺癌风险估计值降低相关（比值比（OR）=0.77，95%置信区间（CI）：0.63，0.95）。对于常见的过敏原，包括室内灰尘，（OR=0.72，95% CI：0.54，0.94），猫（OR=0.59，95%CI：0.41，0.85）、植物（OR=0.77，95%CI：0.62，0.96）和霉菌（OR=0.49，95%CI：0.32，0.75）以及所有过敏症状，尽管一些置信区间包括1。观察到与过敏数量增加（p=0.0006）和过敏症状严重程度增加（p=0.003）相关的风险降低趋势。这些结果为与过敏相关的免疫功能可能在胰腺癌病因学中发挥作用的可能性提供了支持。
Data from a large population-based case-control study conducted in the San Francisco Bay Area between 1994 and 2001 were analyzed to examine the association between pancreatic cancer and history of allergic conditions. Pancreatic cancer cases (n=532) had to be 21-85 years of age and were identified using rapid case ascertainment. Random digit dialing and Health Care Financing Administration lists (age, greater than or equal to65 years) were used to obtain 1,701 controls who were frequency-matched to cases by sex and age within 5 years. In-person interviews were conducted and detailed allergy history data were obtained for all participants. Prior history of any allergy was associated with a reduced risk estimate for pancreatic cancer (odds ratio (OR)=0.77, 95% confidence interval (CI): 0.63, 0.95). Inverse associations were observed for common allergens, including house dust (OR=0.72, 95% CI: 0.54, 0.94), cats (OR=0.59, 95% CI: 0.41, 0.85), plants (OR=0.77, 95% CI: 0.62, 0.96), and mold (OR=0.49, 95% CI: 0.32, 0.75), and for all allergic symptoms, although some confidence intervals included unity. Trends were observed for decreased risks associated with increasing number of allergies (p=0.0006) and severity of allergic symptoms (p=0.003). These results provide support for the plausibility that immune function in relation to allergies may play a role in the etiology of pancreatic cancer.