Lipids, adiposity and tendinopathy: is there a mechanistic link? Critical review.
Lipids, adiposity and tendinopathy: is there a mechanistic link? Critical review.
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DOI：
10.1136/bjsports-2014-093989
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发表时间：
2015-08
影响因子：
18.4
通讯作者：
Hart DA
中科院分区：
文献类型：
--
作者：
Scott A;Zwerver J;Grewal N;de Sa A;Alktebi T;Granville DJ;Hart DA
超重或肥胖与肌腱病变的风险增加有关。然而，对于运动员，一方面将体重或肥胖与另一方面肌腱病变风险联系起来的流行病学数据不太一致。事实上，饮食、肥胖和肌腱病理之间的机械联系在很大程度上仍未得到研究。最近的研究已经开始检查饮食干预对肌腱生物力学或疼痛等结果的影响。氧化低密度脂蛋白已被证明（A）在食用脂肪饮食的小鼠的肌腱组织中积累，（B）在人类肌腱细胞中诱导病理表型。本文讨论了目前的争论：过度的身体质量指数（导致肌腱组织负荷和应变增加）本身的潜在机制？或者脂肪对肌腱的局部或全身影响会导致肌腱病变吗？这篇叙述性综述认为，血脂过高可能是临床研究的一个重要途径。
Being overweight or obese is associated with an elevated risk of tendon pathology. However, for sportspeople the epidemiological data linking weight or adiposity on one hand, and risk of tendon pathology on the other, are less consistent. Indeed, the mechanistic links between diet, adiposity and tendon pathology remain largely unexamined. Recent studies have begun to examine the effects of dietary interventions on outcomes such as tendon biomechanics or pain. Oxidised low-density lipoprotein has been shown to (A) accumulate in the tendon tissues of mice that eat a fatty diet and (B) induce a pathological phenotype in human tendon cells. This paper addresses the current debate: is excessive body mass index (causing increased load and strain on tendon tissue) per se the underlying mechanism? Or do local or systemic influences of fat on tendons predispose to tendon pathology? This narrative review argues that excessive blood lipids may be an important avenue for clinical investigations.
DOI：
10.3390/ijerph8114300
发表时间：
2011-11
影响因子：
--
作者：
Pappa E;Kontodimopoulos N;Papadopoulos AA;Tountas Y;Niakas D
通讯作者：
Niakas D