Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
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DOI：
10.1002/jmv.20499
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发表时间：
2006-01-01
影响因子：
12.7
通讯作者：
Ho, D
中科院分区：
文献类型：
--
作者：
Zhang, LQ;Zhang, FW;Ho, D
大多数SARS-CoV感染患者在没有临床干预的情况下自发康复，而一小部分人死于这种疾病。在这里，我们的特点是在N蛋白特异性和S糖蛋白特异性中和抗体（Nab）反应的感染患者中的时间变化，这些患者已经从SARS-CoV感染中恢复或死亡。研究发现，SARS患者的N蛋白特异性和S糖蛋白特异性Nab应答水平较高且可持续，这表明抗体应答可能在决定SARS患者的最终疾病结局方面发挥重要作用。
Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.