Familial Clustering of Tic Disorders and Obsessive-Compulsive Disorder
Familial Clustering of Tic Disorders and Obsessive-Compulsive Disorder
复制标题
DOI：
10.1001/jamapsychiatry.2014.2656
复制
发表时间：
2015-04-01
期刊：
影响因子：
25.8
通讯作者：
Grice, Dorothy E.
中科院分区：
文献类型：
--
作者：
Browne, Heidi A.;Hansen, Stefan N.;Grice, Dorothy E.
重要性图雷特综合征/慢性抽动障碍（TS/CT）和强迫症（OCD）在其现象学特征上重叠，并且经常在受影响的个人和家庭中共同发生。了解这些疾病如何在家庭中聚集提供了重要的临床信息，是了解这些disorders.Objective的原因的重要一步，以确定TS/CT和强迫症的家庭复发使用一个国家的流行病学sample.DESIGN，SETTING，AND PARTICIPANTS设计，设置，和参与者我们进行了一项以人口为基础的研究，健康登记在丹麦，包括1980年1月1日至2007年12月31日期间出生于丹麦并随访至2013年12月31日的所有个体（n = 1 741 271）。主要结果和指标：与无TS/CT或OCD的个体相比，有TS/CT或OCD的个体TS/CT和OCD的患病率和TS/CT或OCD的相对复发风险（RRR）。和412，两种疾病。TS/CT的总体队列患病率为0.42%（95%CI，0.41%-0.43%），OCD的总体队列患病率为0.84%（95%CI，0.81%-0.87%）。在所有出生年份中，TS/CT的平均兄弟姐妹复发风险为9.88%（95%CI，8.02%-12.16%），OCD为4.01%（95%CI，2.78%-5.76%）。TS/CT的同胞RR为18.63（95% CI，15.34-22.63）。相比之下，强迫症的同胞RR为4.89（95% CI，3.45-6.93）。TS/CT的亲子RR为61.02（95%CI，44.43-83.82），而OCD的亲子RR为6.25（95%CI，4.82-8.11）。兄弟姐妹和父母-子女交叉障碍的风险也是显著的，范围从3.20（95%CI，2.22-4.62）到10.27（95%CI，5.17-20.39）。TS/CT的家族聚集性显著高于强迫症的家族聚集性。复发风险估计为识别风险个体提供了重要的临床框架，并提供了对这些疾病原因的见解。
IMPORTANCE Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important step in understanding the causes of these disorders.OBJECTIVE To determine familial recurrence for TS/CT and OCD using a national epidemiologic sample.DESIGN, SETTING, AND PARTICIPANTS We performed a population-based study of health registries in Denmark, including all individuals (n = 1 741 271) born in Denmark from January 1, 1980, through December 31, 2007, and followed up through December 31, 2013. We identified those with TS/CT and/or OCD.MAIN OUTCOMES AND MEASURES The prevalence of TS/CT and OCD and relative recurrence risk (RRR) for TS/CT or OCD among individuals with an oldest sibling or a parent diagnosed as having TS/CT or OCD compared with individuals without an affected oldest sibling or an affected parent.RESULTS In this sample, 5596 individuals were diagnosed as having TS/CT; 6191, OCD; and 412, both disorders. The overall cohort prevalence of TS/CT was 0.42%(95% CI, 0.41%-0.43%) and of OCD, 0.84%(95% CI, 0.81%-0.87%). The mean sibling recurrence risk for TS/CT across all birth years was 9.88%(95% CI, 8.02%-12.16%) and for OCD, 4.01% (95% CI, 2.78%-5.76%). The sibling RRR for TS/CT was 18.63 (95% CI, 15.34-22.63). In contrast, the sibling RRR for OCD was 4.89 (95% CI, 3.45-6.93). The parent-offspring RRR for TS/CT was 61.02 (95% CI, 44.43-83.82), whereas the parent-offspring RRR for OCD was 6.25 (95% CI, 4.82-8.11). The sibling and parent-offspring cross-disorder risks were also significant, ranging from 3.20 (95% CI, 2.22-4.62) to 10.27 (95% CI, 5.17-20.39).CONCLUSIONS AND RELEVANCE Tourette syndrome/CT and OCD cluster in families. The familial aggregation of TS/CT is profound and substantially higher than the familial aggregation for OCD. The recurrence risk estimates provide an important clinical framework for identifying individuals at risk and provide insights into the causes of these disorders.